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CD8 T Cells Producing IL-17 and IFN-γ Initiate the Innate Immune Response Required for Responses to Antigen Skin Challenge
| Content Provider | Scilit |
|---|---|
| Author | Kish, Danielle D. Li, Xiaoxia Fairchild, Robert L. |
| Copyright Year | 2009 |
| Description | Effector CD8 T cell recruitment into the skin in response to Ag challenge requires prior CXCL1/KC-directed neutrophil infiltration. Mechanisms inducing CXCL1 production and the dynamics of neutrophil-CD8 T cell interactions during elicitation of Ag-specific responses in the skin were investigated. CXCL1 and CXCL2/MIP-2 were produced within 3–6 h of Ag challenge at 10-fold higher levels in skin challenge sites of Ag-sensitized vs nonsensitized mice. In the challenge sites of sensitized mice this production decreased at 6–9 h postchallenge to near the levels observed in skin challenge sites of nonsensitized mice but rose to a second peak 12 h after challenge. The elevated early neutrophil chemoattractant production at 3–6 h after skin challenge of sensitized animals required both IFN-γ and IL-17, produced by distinct populations of Ag-primed CD8 T cells in response to Ag challenge. Although induced by the Ag-primed CD8 T cells, the early CXCL1 and CXCL2 production was accompanied by neutrophil but not CD8 T cell infiltration into the skin Ag challenge site. Infiltration of the CD8 T cells into the challenge site was not observed until 18–24 h after challenge. These results demonstrate an intricate series of early interactions between Ag-specific and innate immune components that regulate the sequential infiltration of neutrophils and then effector T cells into the skin to mediate an immune response. |
| Ending Page | 5959 |
| Page Count | 11 |
| Starting Page | 5949 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.0802830 |
| Journal | The Journal of Immunology |
| Issue Number | 10 |
| Volume Number | 182 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2009-05-15 |
| Access Restriction | Open |
| Subject Keyword | Cd8 T Cells Il-17 Ifn-γ |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
