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Nonspecific Recruitment of Memory CD8+ T Cells to the Lung Airways During Respiratory Virus Infections
| Content Provider | Scilit |
|---|---|
| Author | Ely, Kenneth H. Cauley, Linda S. Roberts, Alan D. Brennan, Jean W. Cookenham, Tres Woodland, David L. |
| Copyright Year | 2003 |
| Description | Previous studies have shown that heterologous viral infections have a significant impact on pre-existing memory T cell populations in secondary lymphoid organs through a combination of cross-reactive and bystander effects. However, the impact of heterologous viral infections on effector/memory T cells in peripheral sites is not well understood. In this study, we have analyzed the impact of a heterologous influenza virus infection on Sendai virus-specific $CD8^{+}$ effector/memory cells present in the lung airways. The data show a transient increase in the numbers of Sendai virus nucleoprotein $324–332/K^{b}$-specific $CD8^{+}$ memory T cells in the airways of the influenza-infected mice peaking around day 4 postinfection. Intratracheal transfer studies and 5-bromo-2′-deoxyuridine incorporation demonstrate that this increase is due to the recruitment of resting memory cells into the airways. In addition, the data show that these immigrating memory cells are phenotypically distinct from the resident memory T cells of the lung airways. A similar influx of nonproliferating Sendai virus nucleoprotein $324–332/K^{b}$-specific $CD8^{+}$ memory T cells is also induced by a secondary (homologous) infection with Sendai virus. Together, these data suggest that inflammation can accelerate memory T cell migration to nonlymphoid tissues and is a part of the normal recall response during respiratory infections. |
| Ending Page | 1429 |
| Page Count | 7 |
| Starting Page | 1423 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.170.3.1423 |
| Journal | The Journal of Immunology |
| Issue Number | 3 |
| Volume Number | 170 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2003-02-01 |
| Access Restriction | Open |
| Subject Keyword | Memory T Cells Sendai Virus Cells of the Lung Airways |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
