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Different Dynamics of CD4+ and CD8+ T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus Infection
| Content Provider | Scilit |
|---|---|
| Author | Boer, Rob J. De Homann, Dirk Perelson, Alan S. |
| Copyright Year | 2003 |
| Description | We fit a mathematical model to data characterizing the primary cellular immune response to lymphocytic choriomeningitis virus. The data enumerate the specific $CD8^{+}$ T cell response to six MHC class I-restricted epitopes and the specific $CD4^{+}$ T cell responses to two MHC class II-restricted epitopes. The peak of the response occurs around day 8 for $CD8^{+}$ T cells and around day 9 for $CD4^{+}$ T cells. By fitting a model to the data, we characterize the kinetic differences between $CD4^{+}$ and $CD8^{+}$ T cell responses and among the immunodominant and subdominant responses to the various epitopes. $CD8^{+}$ T cell responses have faster kinetics in almost every aspect of the response. For $CD8^{+}$ and $CD4^{+}$ T cells, the doubling time during the initial expansion phase is 8 and 11 h, respectively. The half-life during the contraction phase following the peak of the response is 41 h and 3 days, respectively. $CD4^{+}$ responses are even slower because their contraction phase appears to be biphasic, approaching a 35-day half-life 8 days after the peak of the response. The half-life during the memory phase is 500 days for the $CD4^{+}$ T cell responses and appears to be lifelong for the six $CD8^{+}$ T cell responses. Comparing the responses between the various epitopes, we find that immunodominant responses have an earlier and/or larger recruitment of precursors cells before the expansion phase and/or have a faster proliferation rate during the expansion phase. |
| Ending Page | 3935 |
| Page Count | 8 |
| Starting Page | 3928 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.171.8.3928 |
| Journal | The Journal of Immunology |
| Issue Number | 8 |
| Volume Number | 171 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2003-10-15 |
| Access Restriction | Open |
| Subject Keyword | Cell Responses |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
