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Cutting Edge: CD8 T Cells Specific for Lymphocytic Choriomeningitis Virus Require Type I IFN Receptor for Clonal Expansion
| Content Provider | Scilit |
|---|---|
| Author | Aichele, Peter Unsoeld, Heike Koschella, Marie Schweier, Oliver Kalinke, Ulrich Vucikuja, Smiljka |
| Copyright Year | 2006 |
| Description | The role of type I IFN signaling in CD8 T cells was analyzed in an adoptive transfer model using P14 TCR transgenic CD8 T cells specific for lymphocytic choriomeningitis virus (LCMV) but deficient in type I IFNR. In the present study, we demonstrate severe impairment in the capacity of P14 T cells lacking type I IFNR to expand in normal type I IFNR wild-type C57BL/6 hosts after LCMV infection. In contrast, following infection of recipient mice with recombinant vaccinia virus expressing LCMV glycoprotein, P14 T cell expansion was considerably less dependent on type I IFNR expression. Lack of type I IFNR expression by P14 T cells did not affect cell division after LCMV infection but interfered with clonal expansion. Thus, direct type I IFN signaling is essential for CD8 T cell survival in certain viral infections. |
| Ending Page | 4529 |
| Page Count | 5 |
| Starting Page | 4525 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.176.8.4525 |
| Journal | The Journal of Immunology |
| Issue Number | 8 |
| Volume Number | 176 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2006-04-15 |
| Access Restriction | Open |
| Subject Keyword | Infectious Diseases Type I Ifn Signaling Cd8 T Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
