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Bone Marrow-Derived IFN-Producing Killer Dendritic Cells Account for the Tumoricidal Activity of Unpulsed Dendritic Cells
| Content Provider | Scilit |
|---|---|
| Author | Himoudi, Nourredine Nabarro, Stephen Buddle, Jo Eddaoudi, Ayad Thrasher, Adrian J. Anderson, John |
| Copyright Year | 2008 |
| Description | The $CD11c^{int}B220^{+}NK1.1^{+}CD49^{+}$ subset of cells has recently been described as IFN-producing killer dendritic cells (IKDC), which share phenotypic and functional properties of dendritic cells and NK cells. Herein we show that bone marrow-derived murine dendritic cell preparations contain abundant $CD11c^{int}B220^{+}NK1.1^{+}CD49^{+}$ cells, the removal of which results in loss of tumoricidal activity of unpulsed dendritic cells in vivo. Moreover, following s.c. injection, as few as 5 × $10^{3}$ highly pure bone marrow-derived IKDC cells are capable of shrinking small contralateral syngeneic tumors in C57BL/6 mice, but not in immunodeficient mice, implying the obligate involvement of host effector cells in tumor rejection. Our data suggest that bone marrow-derived IKDC represent a population that has powerful tumoricidal activity in vivo. |
| Ending Page | 6663 |
| Page Count | 10 |
| Starting Page | 6654 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.181.9.6654 |
| Alternate Webpage(s) | http://www.jimmunol.org/content/181/9/6654.full.pdf |
| Journal | The Journal of Immunology |
| Issue Number | 9 |
| Volume Number | 181 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2008-11-01 |
| Access Restriction | Open |
| Subject Keyword | Dendritic Cells Bone Marrow Derived |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
