Cutting Edge: STAT1 and T-bet Play Distinct Roles in Determining Outcome of Visceral Leishmaniasis Caused byLeishmania donovani

Content Provider	Scilit
Author	Rosas, Lucia E. Snider, Heidi M. Barbi, Joseph Satoskar, Anjali A. Lugo-Villarino, Geanncarlo Keiser, Tracy Papenfuss, Tracy Durbin, Joan E. Radzioch, Danuta Glimcher, Laurie H. Satoskar, Abhay R.
Copyright Year	2006
Description	T-bet and STAT1 regulate IFN-γ gene transcription in $CD4^{+}$ T cells, which mediate protection against Leishmania. Here we show that T-bet and STAT1 are required for the induction of an efficient Th1 response during Leishmania donovani infection, but they play distinct roles in determining disease outcome. Both $STAT1^{−/−}$ and $T-bet^{−/−}$ mice failed to mount a Th1 response, but $STAT1^{−/−}$ mice were highly resistant to L. donovani and developed less immunopathology, whereas $T-bet^{−/−}$ mice were highly susceptible and eventually developed liver inflammation. Adoptive cell transfer studies showed that $RAG2^{−/}$− recipients receiving $STAT1^{+/+}$ or $STAT1^{−/}$− T cells developed comparable liver pathology, but those receiving $STAT1^{−/}$− T cells were significantly more susceptible to infection. These unexpected findings reveal distinct roles for T-bet and STAT1 in mediating host immunity and liver pathology during visceral leishmaniasis.
Ending Page	25
Page Count	4
Starting Page	22
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.177.1.22
Journal	The Journal of Immunology
Issue Number	1
Volume Number	177
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2006-07-01
Access Restriction	Open
Subject Keyword	Bet and Stat1 Distinct Roles
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology