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TLR-Dependent Activation Stimuli Associated with Th1 Responses Confer NK Cell Stimulatory Capacity to Mouse Dendritic Cells
| Content Provider | Scilit |
|---|---|
| Author | Zanoni, Ivan Foti, Maria Ricciardi-Castagnoli, Paola Granucci, Francesca |
| Copyright Year | 2005 |
| Description | Dendritic cells (DCs) have an important role in the activation of NK cells that exert direct antitumor and antimicrobial effects and can influence the development of adaptive T cell responses. DCs acquire NK cell stimulatory capacity after exposure to various stimuli. In this study we investigated the nature of the stimuli that confer to DCs the NK cell-activating capacity. After exposure of DCs to TLR-dependent and -independent microbial stimuli and to nonmicrobial stimuli, we evaluated the ability of activated DCs to elicit IFN-γ production from NK cells in vitro and to promote NK cell activation in vivo. We show in this study that only TLR-dependent microbial stimuli typically associated with Th1 responses confer to DCs the ability to activate NK cells, whereas stimuli associated with Th2 responses do not have this property. |
| Ending Page | 292 |
| Page Count | 7 |
| Starting Page | 286 |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.175.1.286 |
| Journal | The Journal of Immunology |
| Issue Number | 1 |
| Volume Number | 175 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2005-07-01 |
| Access Restriction | Open |
| Subject Keyword | Activation of Nk Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
