NDLI: Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

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Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

Content Provider	Scilit
Author	Deng, Wei Bao, Linlin Liu, Jiangning Xiao, Chong Liu, Jiayi Xue, Jing Lv, Qi Qi, Feifei Gao, Hong Yu, Pin Xu, Yanfeng Qu, Yajin Li, Fengdi Xiang, Zhiguang Yu, Haisheng Gong, Shuran Liu, Mingya Wang, Guanpeng Wang, Shunyi Song, Zhiqi Liu, Ying Zhao, Wenjie Han, Yunlin Zhao, Linna Liu, Xing Wei, Qiang Qin, Chuan
Copyright Year	2020
Description	Coronavirus disease 2019 (COVID-19), which is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. It is unclear whether convalescing patients have a risk of reinfection. We generated a rhesus macaque model of SARS-CoV-2 infection that was characterized by interstitial pneumonia and systemic viral dissemination mainly in the respiratory and gastrointestinal tracts. Rhesus macaques reinfected with the identical SARS-CoV-2 strain during the early recovery phase of the initial SARS-CoV-2 infection did not show detectable viral dissemination, clinical manifestations of viral disease, or histopathological changes. Comparing the humoral and cellular immunity between primary infection and rechallenge revealed notably enhanced neutralizing antibody and immune responses. Our results suggest that primary SARS-CoV-2 exposure protects against subsequent reinfection in rhesus macaques.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402625/pdf https://science.sciencemag.org/content/sci/early/2020/07/01/science.abc5343.full.pdf
Ending Page	823
Page Count	6
Starting Page	818
ISSN	00368075
e-ISSN	10959203
DOI	10.1126/science.abc5343
Journal	Science
Issue Number	6505
Volume Number	369
Language	English
Publisher	American Association for the Advancement of Science (AAAS)
Publisher Date	2020-07-02
Access Restriction	Open
Subject Keyword	Journal: Science Rhesus Macaques Sars Cov
Content Type	Text
Resource Type	Article
Subject	History and Philosophy of Science

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