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A global genetic interaction network maps a wiring diagram of cellular function
| Content Provider | Scilit |
|---|---|
| Author | Costanzo, Michael Sluis, Benjamin Vander Koch, Elizabeth N. Baryshnikova, Anastasia Pons, Carles Tan, Guihong Wang, Wen Hanchard, Julia Lee, Susan D. Pelechano, Vicent Styles, Erin B. Billmann, Maximilian van Leeuwen, Jolanda van Dyk, Nydia Lin, Zhen-Yuan Kuzmin, Elena Nelson, Justin Piotrowski, Jeff S. Srikumar, Tharan Bahr, Sondra Chen, Yiqun Deshpande, Raamesh Kurat, Christoph F. Li, Sheena C. Li, Zhijian Okada, Hiroki Pascoe, Natasha Luis, Bryan-Joseph San Sharifpoor, Sara Shuteriqi, Emira Simpkins, Scott W. Snider, Jamie Suresh, Harsha Garadi Tan, Yizhao Zhu, Hongwei Malod-Dognin, Noel Janjic, Vuk Przulj, Natasa Troyanskaya, Olga G. Stagljar, Igor Xia, Tian Ohya, Yoshikazu Gingras, Anne-Claude Raught, Brian Boutros, Michael Steinmetz, Lars M. Moore, Claire L. Rosebrock, Adam P. Caudy, Amy A. Myers, Chad L. Andrews, Brenda Boone, Charles |
| Editor | Usaj, M. M. |
| Copyright Year | 2016 |
| Description | We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing more than 23 million double mutants, identifying about 550,000 negative and about 350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential genes as densely connected hubs. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to protein complexes and pathways, biological processes, and cellular compartments. Negative interactions connected functionally related genes, mapped core bioprocesses, and identified pleiotropic genes, whereas positive interactions often mapped general regulatory connections among gene pairs, rather than shared functionality. The global network illustrates how coherent sets of genetic interactions connect protein complex and pathway modules to map a functional wiring diagram of the cell. |
| Related Links | https://science.sciencemag.org/content/sci/353/6306/aaf1420.full.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661885/pdf |
| Ending Page | aaf1420 |
| Page Count | 1 |
| Starting Page | aaf1420 |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| DOI | 10.1126/science.aaf1420 |
| Journal | Science |
| Issue Number | 6306 |
| Volume Number | 353 |
| Language | English |
| Publisher | American Association for the Advancement of Science (AAAS) |
| Publisher Date | 2016-09-22 |
| Access Restriction | Open |
| Subject Keyword | Journal: Science Genetic Interactions |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
