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The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus neoformans
| Content Provider | Scilit |
|---|---|
| Author | D'Souza, Cletus A. Loftus, Brendan J. Fung, Eula Roncaglia, Paola Rowley, Don Amedeo, Paolo Bruno, Dan Vamathevan, Jessica Miranda, Molly Anderson, Iain J. Fraser, James A. Allen, Jonathan E. Bosdet, Ian E. Brent, Michael R. Chiu, Readman Doering, Tamara L. Donlin, Maureen J. Fox, Deborah S. Grinberg, Viktoriya Fu, Jianmin Fukushima, Marilyn Haas, Brian J. Huang, James C. Janbon, Guilhem Koo, Hean L. Krzywinski, Martin I. Kwon-Chung, June K. Lengeler, Klaus B. Maiti, Rama Marra, Marco A. Marra, Robert E. Mathewson, Carrie A. Mitchell, Thomas G. Pertea, Mihaela Riggs, Florenta R. Salzberg, Steven L. Schein, Jacqueline E. Shvartsbeyn, Alla Shin, Heesun Shumway, Martin Specht, Charles A. Suh, Bernard B. Tenney, Aaron Utterback, Terry R. Wickes, Brian L. Wortman, Jennifer R. Wye, Natasja H. Kronstad, James W. Heitman, Joseph Davis, Ronald W. Fraser, Claire M. Hyman, Richard W. |
| Editor | Jones, Steven J. M. |
| Copyright Year | 2005 |
| Description | Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its â¼20-megabase genome, which contains â¼6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposons may drive karyotype instability and phenotypic variation. C. neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes. |
| Related Links | http://europepmc.org/articles/pmc3520129?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520129/pdf https://science.sciencemag.org/content/sci/307/5713/1321.full.pdf |
| Ending Page | 1324 |
| Page Count | 4 |
| Starting Page | 1321 |
| ISSN | 00368075 |
| e-ISSN | 10959203 |
| DOI | 10.1126/science.1103773 |
| Journal | Science |
| Issue Number | 5713 |
| Volume Number | 307 |
| Language | English |
| Publisher | American Association for the Advancement of Science (AAAS) |
| Publisher Date | 2005-02-25 |
| Access Restriction | Open |
| Subject Keyword | Journal: Science Cryptococcus Neoformans Basidiomycetous Yeast Human Pathogen |
| Content Type | Text |
| Resource Type | Article |
| Subject | History and Philosophy of Science |
