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Redox pathways of aliskiren based on experimental and computational approach and its voltammetric determination
| Content Provider | Scientific Electronic Library Online (SciELO) |
|---|---|
| Author | Pamuk, Deniz Taşdemir, İbrahim Hüdai Ece, Abdulilah Canel, Esin Kılıç, Esma |
| Abstract | Electrochemical behavior of aliskiren (ALS) was studied via experimental electrochemical methods and theoretical calculations performed at B3LYP/6-31+G (d)//AM1. Cyclic voltammetry studies were carried out based on the adsorption-controlled reversible reduction at ca. -1.5 V on hanging mercury drop electrode (HMDE) and irreversible electrochemical oxidation of ALS at ca. 1.0 V on glassy carbon electrode (GCE), vs. Ag/AgCl, KCl (3.0 mol L-1), in Britton-Robinson buffer at pH 10 and 8, respectively. According to computational and experimental findings, ALS is expected to be oxidized irreversibly at benzylic position and reduced reversibly at amide carbonyl groups. Voltammetric methods with and without adsorptive stripping mode were developed and validated for quantification of ALS in different samples. Limits of detection and of quantification for ALS were 6.3 × 10-8 and 2.1 × 10-7 mol L-1 for differential pulse voltammetry on HMDE and 1.2 × 10-8 and 3.9 × 10-8 mol L-1 for square-wave cathodic adsorptive stripping voltammetry. The methods were successfully applied to assay the drug in tablets and human serum with good recoveries, between 91.7 and 102.3%, having relative standard deviation less than 10%. |
| Related Links | http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532013000800008&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532013000800008&lng=en&nrm=iso |
| Starting Page | 1276 |
| Ending Page | 1286 |
| Page Count | 11 |
| File Format | |
| ISSN | 01035053 |
| DOI | 10.5935/0103-5053.20130162 |
| Journal | Journal of the Brazilian Chemical Society |
| Issue Number | 8 |
| Volume Number | 24 |
| Language | English |
| Publisher | Sociedade Brasileira de Química |
| Publisher Date | 2013-08-01 |
| Publisher Institution | Ankara University Faculty of Science Department of Chemistry Amasya University Faculty of Artsand Science Department of Chemistry Hacettepe University Faculty of Science Department of Chemistry |
| Publisher Place | Turkey |
| Access Restriction | Open |
| Subject Keyword | Aliskiren Density functional theory Electrochemical behavior Electrode mechanism HOMO-LUMO Voltammetric determination |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry |
