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| Content Provider | Scientific Electronic Library Online (SciELO) |
|---|---|
| Author | Amarante, Marla Karine Ariza, Carolina Batista Oliveira, Carlos Eduardo Coral de Gualtieri, Karina de Almeida Oda, Julie Massayo Maeda Watanabe, Maria Angelica Ehara |
| Abstract | ABSTRACT Inulin is an effective prebiotic and its potential in modulating systemic immunity have been proposed. A subpopulation of T cells, named T regulatory cells (Tregs), expressing the Forkhead boxP3 transcription factor are key mediators of peripheral tolerance and suppress undesirable immune responses. These Tregs can be induced by cytokine transforming growth factor beta (TGF-β) and interleukin 10 (IL-10). This work aimed to evaluate inulin effects on human peripheral blood mononuclear cells (PBMC) in vitro. PBMC were incubated with inulin, and the expression of TGF-(1, FOXP3 and IL-10 was analyzed. Increased supernatant IL-10 levels were observed in PBMC of inulin-treated group (p=0.03). Moreover, FOXP3 gene expression was 7.6 fold higher in inulin-treated PBMC, whereas a trend in TGF-β1 expression was detected (p=0.055). These data suggest that inulin induces an immunosuppressive environment in cultured PBMC by promoting FOXP3 gene expression and IL-10 secretion. These studies offer prospects for further fundamental research in this field. |
| Related Links | http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1516-89132018000100417&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100417&lng=en&nrm=iso |
| File Format | |
| ISSN | 15168913 |
| DOI | 10.1590/1678-4324-2018160591 |
| Journal | Brazilian Archives of Biology and Technology |
| Volume Number | 61 |
| Language | English |
| Publisher Date | 2018-01-01 |
| Publisher Institution | Instituto de Tecnologia do Paraná - Tecpar |
| Access Restriction | Open |
| Subject Keyword | Inulin FOXP3 IL-10 PBMC |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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