NDLI: Serum regucalcin is a useful indicator of liver injury severity in patients with hepatitis B virus-related liver diseases

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Plasma levels and placental expression of vaspin in pregnant women with diabetes mellitus

Association between the increase in brain temperature and physical performance at different exercise intensities and protocols in a temperate environment

Reduction of blood nitric oxide levels is associated with clinical improvement of the chronic pelvic pain related to endometriosis

Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A

Classical and recent advances in the treatment of inflammatory bowel diseases

Influence of population and exercise protocol characteristics on hemodynamic determinants of post-aerobic exercise hypotension

Coronary artery plaque burden and calcium scores in healthy men adhering to long-term wine drinking or alcohol abstinence

Sorafenib prevents liver fibrosis in a non-alcoholic steatohepatitis (NASH) rodent model

Gene expression of estrogen and oxytocin receptors in the uterus of pregnant and parturient bitches

Voluntary exercise prior to traumatic brain injury alters miRNA expression in the injured mouse cerebral cortex

Hepatitis B virus DNA stability in plasma samples under short-term storage at 42°C

Esculetin, a coumarin derivative, exerts in vitro and in vivo antiproliferative activity against hepatocellular carcinoma by initiating a mitochondrial-dependent apoptosis pathway

Prevention of etomidate-induced myoclonus during anesthetic induction by pretreatment with dexmedetomidine

Effects of 5-aza-2′deoxycytidine on RECK gene expression and tumor invasion in salivary adenoid cystic carcinoma

Rosai-Dorfman disease: a report of eight cases in a tertiary care center and a review of the literature

Central release of nitric oxide mediates antinociception induced by aerobic exercise

Hormone therapy with tamoxifen reduces plasma levels of NT-B-type natriuretic peptide but does not change ventricular ejection fraction after chemotherapy in women with breast cancer

Effect of salt intake and potassium supplementation on brachial-ankle pulse wave velocity in Chinese subjects: an interventional study

Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system

Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition

Effects of conventional vs high-dose rocuronium on the QTc interval during anesthesia induction and intubation in patients undergoing coronary artery surgery: a randomized, double-blind, parallel trial

Protective roles of pulmonary rehabilitation mixture in experimental pulmonary fibrosis in vitro and in vivo

The role of necroptosis in neurosurgical diseases

Interaction between affordance and handedness recognition: a chronometric study

IL-6 and TNF-α serum levels are associated with early death in community-acquired pneumonia patients

Long-term, regular remote ischemic preconditioning improves endothelial function in patients with coronary heart disease

Introduction to the IX Meeting of the "Sociedade Brasileira de Biociências Nucleares". Caxambu, MG, Brazil, August 27-30, 2014

Circulating endothelial cells are increased in chronic myeloid leukemia blast crisis

DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations

Hydrogen sulfide in posthemorrhagic shock mesenteric lymph drainage alleviates kidney injury in rats

Three days of intermittent stretching after muscle disuse alters the proteins involved in force transmission in muscle fibers in weanling rats

CTLA4 enhances the osteogenic differentiation of allogeneic human mesenchymal stem cells in a model of immune activation

High prevalence of methicillin resistance and PVL genes among Staphylococcus aureus isolates from the nares and skin lesions of pediatric patients with atopic dermatitis

A glycoprotein E gene-deleted bovine herpesvirus 1 as a candidate vaccine strain

Comparison of conventional Papanicolaou cytology samples with liquid-based cervical cytology samples from women in Pernambuco, Brazil

Development of the endocrine pancreas and novel strategies for β-cell mass restoration and diabetes therapy

Dynamic resistance training decreases sympathetic tone in hypertensive ovariectomized rats

Intensity of swimming exercise influences aortic reactivity in rats

Effect of estradiol and bisphenol A on human hepatoblastoma cell viability and telomerase activity

B cells expressing IL-10 mRNA modulate memory T cells after DNA-Hsp65 immunization

Nucleotide excision repair pathway assessment in DNA exposed to low-intensity red and infrared lasers

Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis

Inflammation induced by increased frequency of intermittent hypoxia is attenuated by tempol administration

The effects of 6-gingerol on proliferation, differentiation, and maturation of osteoblast-like MG-63 cells

Plasticity of neutrophils reveals modulatory capacity

Development and applications of the SWAN rating scale for assessment of attention deficit hyperactivity disorder: a literature review

Changes in circulating endothelial progenitor cells predict responses of multiple myeloma patients to treatment with bortezomib and dexamethasone

Decreased brain-derived neurotrophic factor plasma levels in psoriasis patients

Activation of endogenous angiotensin converting enzyme 2 prevents early injuries induced by hyperglycemia in rat retina

Negative emotions affect postoperative scores for evaluating functional knee recovery and quality of life after total knee replacement

Hormonal therapy with estradiol and drospirenone improves endothelium-dependent vasodilation in the coronary bed of ovariectomized spontaneously hypertensive rats

Essential oil of Lippia alba and its main constituent citral block the excitability of rat sciatic nerves

Diabetes mellitus affects the biomechanical function of the callus and the expression of TGF-beta1 and BMP2 in an early stage of fracture healing

Assessment of the diagnostic value of diffusion tensor imaging in patients with spinal cord compression: a meta-analysis

Assessment of indicators of vitamin A status in non-cirrhotic chronic hepatitis C patients

β-Citronellol, an alcoholic monoterpene with inhibitory properties on the contractility of rat trachea

Lyophilized allografts without pre-treatment with glutaraldehyde are more suitable than cryopreserved allografts for pulmonary artery reconstruction

Acute but not chronic metabolic acidosis potentiates the acetylcholine-induced reduction in blood pressure: an endothelium-dependent effect

Concomitant stress potentiates the preference for, and consumption of, ethanol induced by chronic pre-exposure to ethanol

Genetic aberrations in multiple myeloma characterized by cIg-FISH: a Brazilian context

HPV vaccines: a controversial issue?

Analyzing gene expression profiles in dilated cardiomyopathy via bioinformatics methods

Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation

Impact of chronic administration of anabolic androgenic steroids and taurine on blood pressure in rats

Pharmacovigilance of patients with multiple myeloma being treated with bortezomib and/or thalidomide

Clinical applications of retrograde autologous priming in cardiopulmonary bypass in pediatric cardiac surgery

Meta-analysis of the efficacy of proton pump inhibitors for the symptoms of laryngopharyngeal reflux

Inflammatory and oxidative stress airway markers in premature newborns of hypertensive mothers

Effect of exercise training on ventilatory efficiency in patients with heart disease: a review

Aerobic training modulates T cell activation in elderly women with knee osteoarthritis

Investigation on the nasal airflow characteristics of anterior nasal cavity stenosis

Long-term efficacy of endovascular vs open surgical repair for complicated type-B aortic dissection: a single-center retrospective study and meta-analysis

Blood levels of pro-inflammatory and anti-inflammatory cytokines during an oral glucose tolerance test in patients with symptoms suggesting reactive hypoglycemia

Oxygen uptake, respiratory exchange ratio, or total distance: a comparison of methods to equalize exercise volume in Wistar rats

Histidine-tryptophan-ketoglutarate solution decreases mortality and morbidity in high-risk patients with severe pulmonary arterial hypertension associated with complex congenital heart disease: an 11-year experience from a single institution

Fluorescent membrane markers elucidate the association of Borrelia burgdorferi with tick cell lines

Enhancement of anti-OVA IgG2c production in vivo by enalapril

Effects of endurance training on reduction of plasma glucose during high intensity constant and incremental speed tests in Wistar rats

Does the incremental shuttle walk test require maximal effort in young obese women?

Low vaspin levels are related to endothelial dysfunction in patients with ankylosing spondylitis

Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner

Maternal protein restriction during lactation modulated the expression and activity of rat offspring hepatic CYP1A1, CYP1A2, CYP2B1, CYP2B2, and CYP2E1 during development

Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men

Prevalence of genital human papillomavirus among rural and urban populations in southern Yunnan province, China

Effect of magnesium ion on human osteoblast activity

Brain caspase-3 and intestinal FABP responses in preterm and term rats submitted to birth asphyxia

A novel homozygous mutation in the solute carrier family 12 member 3 gene in a Chinese family with Gitelman syndrome

Effects of lung cancer cell-associated B7-H1 on T-cell proliferation in vitro and in vivo

Obesity inversely correlates with prostate-specific antigen levels in a population with normal screening results of prostate cancer in northwestern China

Intramyocardial implantation of differentiated rat bone marrow mesenchymal stem cells enhanced by TGF-β1 improves cardiac function in heart failure rats

Antibody response in silver catfish (Rhamdia quelen) immunized with a model antigen associated with different adjuvants

Sida tuberculata (Malvaceae): a study based on development of extractive system and in silico and in vitro properties

Role of adenylyl cyclase in reduced β-adrenoceptor-mediated vasorelaxation during maturation

LXW7 ameliorates focal cerebral ischemia injury and attenuates inflammatory responses in activated microglia in rats

Effects of fluoride on proliferation and mineralization in periodontal ligament cells in vitro

Effect of different anesthetic agents on left ventricular systolic function assessed by echocardiography in hamsters

Predictors of early treatment discontinuation and severe anemia in a Brazilian cohort of hepatitis C patients treated with first-generation protease inhibitors

Influence of storage time on DNA of Chlamydia trachomatis, Ureaplasma urealyticum, and Neisseria gonorrhoeae for accurate detection by quantitative real-time polymerase chain reaction

Pharmacological study of the mechanisms involved in the vasodilator effect produced by the acute application of triiodothyronine to rat aortic rings

Swimming training attenuates oxidative damage and increases enzymatic but not non-enzymatic antioxidant defenses in the rat brain

Sleep disorder or simple sleep ontogeny? Tendency for morningness is associated with worse sleep quality in the elderly

Macelignan inhibits bee pathogenic fungi Ascophaera apis growth through HOG1 pathway

Human dental pulp stem cells transplantation combined with treadmill training in rats after traumatic spinal cord injury

Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome

Impact of acute undernutrition on growth, ileal morphology and nutrient transport in a murine model

Sentinel node biopsy using blue dye and technetium99 in advanced gastric cancer: anatomical drainage and clinical application

Depression and diagnosis of neurocognitive impairment in HIV-positive patients

Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats

Combination therapy of orally administered glycyrrhizin and UVB improved active-stage generalized vitiligo

Investigation of modified platelet-rich plasma (mPRP) in promoting the proliferation and differentiation of dental pulp stem cells from deciduous teeth

CD19+ B cell subsets in the peripheral blood and skin lesions of psoriasis patients and their correlations with disease severity

Variability in baseline laboratory measurements of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Galunisertib (LY2157299), a transforming growth factor-β receptor I kinase inhibitor, attenuates acute pancreatitis in rats

Renin-angiotensin system blockers regulate the metabolism of isolated fat cells in vitro

Angiotensin-(1–7) inhibits inflammation and oxidative stress to relieve lung injury induced by chronic intermittent hypoxia in rats

Transient elastography and APRI score: looking at false positives and false negatives. Diagnostic performance and association to fibrosis staging in chronic hepatitis C

Cerebral vasomotor reactivity assessment using Transcranial Doppler and MRI with apnea test

Loss to follow-up in anti-HCV-positive patients in a Brazilian regional outpatient clinic

Clinical and prognostic significance of serum transforming growth factor-beta1 levels in patients with pancreatic ductal adenocarcinoma

A review of the application of autologous blood transfusion

Treatment of hepatitis C virus genotype 3 infection with direct-acting antiviral agents

Oxidative stress and skeletal muscle dysfunction are present in healthy smokers

Inactivated Pseudomonas aeruginosa inhibits hypoxia-induced pulmonary hypertension by preventing TGF-β1/Smad signaling

Invasive pulmonary fungal infections in patients with connective tissue disease: a retrospective study from northern China

A novel effective method for the assessment of microvascular function in male patients with coronary artery disease: a pilot study using laser speckle contrast imaging

Selection of superior bifidobacteria in the presence of rotavirus

Surgical treatment of Denis type B thoracolumbar burst fracture with neurological deficiency by paraspinal approach

Construction of a fusion plasmid containing the PSCA gene and cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and its anti-tumor effect in an animal model of prostate cancer

Non-clinical studies required for new drug development - Part I: early in silico and in vitro studies, new target discovery and validation, proof of principles and robustness of animal studies

High-CHO diet increases post-exercise oxygen consumption after a supramaximal exercise bout

T-cell lymphoma with rhabdomyolysis: case report and literature review

Retraction notice for: “Comparison of Arndt-endobronchial blocker plus laryngeal mask airway with left-sided double-lumen endobronchial tube in one-lung ventilation in thoracic surgery in the morbidly obese” [Braz J Med Biol Res (2018) 51(2): e6825]

Knockdown of long non-coding RNA ANRIL inhibits tumorigenesis in human gastric cancer cells via microRNA-99a-mediated down-regulation of BMI1

Mycotic aneurysm due to Salmonella species: clinical experiences and review of the literature

Up-regulated expression of CD147 gene in malignant bone tumor and the possible induction mechanism during osteoclast formation

Transplantation of rat-derived microglial cells promotes functional recovery in a rat model of spinal cord injury

Transcriptomic differential lncRNA expression is involved in neuropathic pain in rat dorsal root ganglion after spared sciatic nerve injury

Imbalance of γδT17/γδTreg cells in the pathogenesis of allergic asthma induced by ovalbumin

Icariin reduces human colon carcinoma cell growth and metastasis by enhancing p53 activities

Ventilation-induced changes correlate to pulmonary vascular response and VEGF, VEGFR-1/2, and eNOS expression in the rat model of postnatal hypoxia

Plasma lipid abnormalities in Pakistani population: trends, associated factors, and clinical implications

Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents

Exenatide ameliorates hepatic steatosis and attenuates fat mass and FTO gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease

Familial history of hypertension-induced impairment on heart rate variability was not observed in strength-trained subjects

Captopril alleviates hypertension-induced renal damage, inflammation, and NF-κB activation

Essential oil of Pterodon polygalaeflorus Benth attenuates nociception in mice

Omphaloceles in combination with a self-made hemispherical cushion: a report of 12 cases

Decreased muscle strength is associated with proinflammatory cytokines but not testosterone levels in men with diabetes

Analysis of radioprotection and antimutagenic effects of Ilex paraguariensis infusion and its component rutin

Strontium ranelate inhibits wear particle-induced aseptic loosening in mice

The aminoglycoside antibiotic gentamicin is able to alter metabolic activity and morphology of MDCK-C11 cells: a cell model of intercalated cells

Intestinal cell migration damage induced by enteropathogenic Escherichia coli strains

Study of major genetic factors involved in pituitary tumorigenesis and their impact on clinical and biological characteristics of sporadic somatotropinomas and non-functioning pituitary adenomas

Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension

Gastrodin induced HO-1 and Nrf2 up-regulation to alleviate H2O2-induced oxidative stress in mouse liver sinusoidal endothelial cells through p38 MAPK phosphorylation

Strontium ranelate as a possible disease-modifying osteoarthritis drug: a systematic review

Baicalein alleviates tubular-interstitial nephritis in vivo and in vitro by down-regulating NF-κB and MAPK pathways

Comparison of endoplasmic reticulum stress and mitochondrial biogenesis responses after 12 weeks of treadmill running and ladder climbing exercises in the cardiac muscle of middle-aged obese rats

Analysis of the application values of different combination schemes of liquid-based cytology and high-risk human papilloma virus test in the screening of high-grade cervical lesions

Participation of hepatic α/β-adrenoceptors and AT1 receptors in glucose release and portal hypertensive response induced by adrenaline or angiotensin II

Erratum for: “Participation of hepatic α/β-adrenoceptors and AT1 receptors in glucose release and portal hypertensive response induced by adrenaline or angiotensin II” [Braz J Med Biol Res (2018) 51(12): e7526]

Acute exercise inhibits gastric emptying of liquids in rats: influence of the NO-cGMP pathway

Allantoin as an independent marker associated with carotid intima-media thickness in subclinical atherosclerosis

Mechanisms involved in anti-aging effects of guarana (Paullinia cupana) in Caenorhabditis elegans

Cat ownership is associated with increased asthma prevalence and dog ownership with decreased spirometry values

Preliminary data for performance in hue ordering tests during pregnancy

Mechanistic effect of the human GJB6 gene and its mutations in HaCaT cell proliferation and apoptosis

Adrenergic receptor β3 is involved in the memory consolidation process in mice

Glycoprotein nonmetastatic melanoma protein B accelerates tumorigenesis of cervical cancer in vitro by regulating the Wnt/β-catenin pathway

MicroRNA-221 promotes cell proliferation, migration, and differentiation by regulation of ZFPM2 in osteoblasts

Saquinavir plus methylprednisolone ameliorates experimental acute lung injury

Anti-ophidian activity of Bredemeyera floribunda Willd. (Polygalaceae) root extract on the local effects induced by Bothrops jararacussu venom

Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer

Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function

NLRP3 inflammasome signaling as an early molecular response is negatively controlled by miR-186 in CFA-induced prosopalgia mice

Hydrogen sulfide protects H9c2 cardiomyoblasts against H2O2-induced apoptosis

Establishment of a rat model for uterine leiomyomas based on Western and traditional Chinese medicine theories

Pros and cons of insulin administration on liver glucose metabolism in strength-trained healthy mice

Latent class analysis of attention and white matter correlation in children with attention-deficit/hyperactivity disorder

Propofol attenuates sepsis-induced acute kidney injury by regulating miR-290-5p/CCL-2 signaling pathway

Lactate-upregulation of lactate oxidation complex-related genes is blunted in left ventricle of myocardial infarcted rats

Astragalus polysaccharides decrease proliferation, migration, and invasion but increase apoptosis of human osteosarcoma cells by up-regulation of microRNA-133a

Cryotherapy: biochemical alterations involved in reduction of damage induced by exhaustive exercise

Red wine consumption, coronary calcification, and long-term clinical evolution

Relationship between heart rate variability and subclinical thyroid disorders of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Effects of nanoparticles of hydroxy-aluminum phthalocyanine on markers of liver injury and glucose metabolism in diabetic mice

HtrA1 suppresses the growth of pancreatic cancer cells by modulating Notch-1 expression

Laboratory evidence for the hematopoietic potential of Beta vulgaris leaf and stalk extract in a phenylhydrazine model of anemia

The safety and efficacy of tPA intravenous thrombolysis for treating acute ischemic stroke patients with a history of cerebral hemorrhage

Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis

Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study

CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis

Importance of the putative furin recognition site 742RNRR745 for antiangiogenic Sema3C activity in vitro

Cirrhotic cardiomyopathy: the liver affects the heart

A pilot study on the identification of human papillomavirus genotypes in tongue cancer samples from a single institution in Ecuador

Circular RNA hsa_circ_0000523 regulates the proliferation and apoptosis of colorectal cancer cells as miRNA sponge

Hereditary angioedema with C1 inhibitor (C1-INH) deficit: the strength of recognition (51 cases)

FGFR1 is an independent prognostic factor and can be regulated by miR-497 in gastric cancer progression

Voluntary wheel running: patterns and physiological effects in mice

Cardiorespiratory and metabolic determinants during moderate and high resistance exercise intensities until exhaustion using dynamic leg press: comparison with critical load

Kaempferol suppresses human gastric cancer SNU-216 cell proliferation, promotes cell autophagy, but has no influence on cell apoptosis

Necroptosis occurs in osteoblasts during tumor necrosis factor-α stimulation and caspase-8 inhibition

Low-intensity pulsed ultrasound promotes proliferation and migration of HaCaT keratinocytes through the PI3K/AKT and JNK pathways

Observation of the effect of bone marrow mesenchymal stem cell transplantation by different interventions on cirrhotic rats

Interleukin-12 as a biomarker of the beneficial effects of food restriction in mice receiving high fat diet or high carbohydrate diet

Protective effect of dexmedetomidine against organ dysfunction in a two-hit model of hemorrhage/resuscitation and endotoxemia in rats

YAP activation promotes the transdifferentiation of cardiac fibroblasts to myofibroblasts in matrix remodeling of dilated cardiomyopathy

Association between tumor necrosis factor polymorphisms and rheumatoid arthritis as well as systemic lupus erythematosus: a meta-analysis

The rs878081 polymorphism of AIRE gene increases the risk of rheumatoid arthritis in a Chinese Han population: a case-control study

NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway

Kinetics of acid-base parameters in conventional hemodialysis

Serotonin induces or inhibits neuritic regeneration of leech CNS neurons depending on neuronal identity

Emodin protects H9c2 cells from hypoxia-induced injury by up-regulating miR-138 expression

Evaluation of platelet activity by multiple electrode impedance aggregometry in acute coronary syndromes: pilot study in a Brazilian tertiary-care public hospital

Prognostic factors in patients undergoing early-start peritoneal dialysis within 24 h after catheter insertion

Visual and automatic classification of the cyclic alternating pattern in electroencephalography during sleep

Effect of risperidone on proliferation and apoptosis of MC3T3-E1 cells

Effects of dipyrone on the digestive tract

Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis

Effects of exposure to fine particulate matter in elderly hospitalizations due to respiratory diseases in the South of the Brazilian Amazon

Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice

Pre-analytical parameters associated with unsuccessful karyotyping in myeloid neoplasm: a study of 421 samples

Fatty acid composition of vegetable oil blend and in vitro effects of pharmacotherapeutical skin care applications

Amifostine reduces inflammation and protects against 5-fluorouracil-induced oral mucositis and hyposalivation

Erratum for: “Effect of JJYMD-C, a novel synthetic derivative of gallic acid, on proliferation and phenotype maintenance in rabbit articular chondrocytes in vitro” [Braz J Med Biol Res (2014) 47(8): e3935]

Retraction notice for: “Risk factors for early-onset ventilator-associated pneumonia in aneurysmal subarachnoid hemorrhage patients” [Braz J Med Biol Res (2018) 51(7): e6830]

Circulating high mobility group box-1 and toll-like receptor 4 expressions increase the risk and severity of epilepsy

Erratum for: “Gastrodin induced HO-1 and Nrf2 up-regulation to alleviate H2O2-induced oxidative stress in mouse liver sinusoidal endothelial cells through p38 MAPK phosphorylation” [Braz J Med Biol Res (2018) 51(10): e7439]

Differential expression of microRNA-411 and 376c is associated with hypertension in pregnancy

Linderae radix ethanol extract attenuates alcoholic liver injury via attenuating inflammation and regulating gut microbiota in rats

Effect of lncRNA HULC knockdown on rat secreting pituitary adenoma GH3 cells

A biomechanical study on proximal junctional kyphosis following long-segment posterior spinal fusion

Antinociceptive and anti-inflammatory activities of a triterpene-rich fraction from Himatanthus drasticus

Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142

Diagnostic accuracy of thromboelastometry and its correlation with the HPLC-MS/MS quantification test

Moderate-intensity exercise allows enhanced protection against oxidative stress-induced cardiac dysfunction in spontaneously hypertensive rats

Small-scale environmental enrichment and exercise enhance learning and spatial memory of Carassius auratus, and increase cell proliferation in the telencephalon: an exploratory study

Egocentric and allocentric spatial memory in healthy aging: performance on real-world tasks

Baroreflex sensitivity in frailty syndrome

Cardiac function and intracellular Ca2+ handling proteins are not impaired by high-saturated-fat diet-induced obesity

Presence of age- and sex-related differences in heart rate variability despite the maintenance of a suitable level of accelerometer-based physical activity

Epigallocatechin-3-gallate ameliorates lipopolysaccharide-induced acute lung injury by suppression of TLR4/NF-κB signaling activation

Segmental resection combined with anoplasty for the treatment of circumferential mixed hemorrhoids

An update on the tools for creating transgenic animal models of human diseases – focus on atherosclerosis

Impact of body characteristics on ultrasound-measured inferior vena cava parameters in Chinese children

Altered peripheral lymphocyte subsets in untreated systemic lupus erythematosus patients with infections

Transcriptional profiling of uterine leiomyoma rats treated by a traditional herb pair, Curcumae rhizoma and Sparganii rhizoma

Plasma brain-derived neurotrophic factor is higher after combat training (Randori) than incremental ramp test in elite judo athletes

Rapid, specific, and sensitive detection of the ureR_1 gene in Klebsiella pneumoniae by loop-mediated isothermal amplification method

Accuracy and prognostic ability of the SARC-F questionnaire and Ishii's score in the screening of sarcopenia in geriatric inpatients

Genetic correlation between Prothrombin G20210A polymorphism and retinal vein occlusion risk

Henoch-Schönlein purpura nephritis associated with monoclonal gammopathy of renal significance: a case report

Molecular detection of Leishmania spp in Lutzomyia longipalpis in the city of Lavras, Minas Gerais, Brazil

Biomass smoke COPD has less tomographic abnormalities but worse hypoxemia compared with tobacco COPD

A study on changes of the resting-state brain function network in patients with amnestic mild cognitive impairment

Impact of enhanced recovery after surgery on postoperative rehabilitation, inflammation, and immunity in gastric carcinoma patients: a randomized clinical trial

Evaluation of the effects of Uncaria rhynchophylla alkaloid extract on LPS-induced preeclampsia symptoms and inflammation in a pregnant rat model

Effects of artepillin C on model membranes displaying liquid immiscibility

Local treatment with ascorbic acid accelerates recovery of post-sutured Achilles tendon in male Wistar rats

T cell receptor excision circles as a tool for evaluating thymic function in young children

Reinforcement omission effects in rats with bilateral lesions in the substantia nigra pars compacta and ventral tegmental area

Diagnostic value of circulating lncRNA ANRIL and its correlation with coronary artery disease parameters

Poly(trimethylene carbonate-co-L-lactide) electrospun scaffolds for use as vascular grafts

The role of KDR in intrauterine adhesions may involve the TGF-β1/Smads signaling pathway

Association between varicose veins anatomical pattern and procedural complications following endovascular laser photothermolysis for chronic venous insufficiency

Screening potential prognostic biomarkers of long non-coding RNAs for predicting the risk of chronic kidney disease

Systemic injection of an H4 receptor agonist induces a decrease in CREB and pCREB levels in the cerebellar vermis and prefrontal cortex in mice

Burden, access, and disparities in kidney disease

Identification of Zika virus in immature phases of Aedes aegypti and Aedes albopictus: a surveillance strategy for outbreak anticipation

MicroRNA-383-5p inhibits the progression of gastric carcinoma via targeting HDAC9 expression

Phenotypic changes of interstitial cells of Cajal after intestinal obstruction in rat model

Pancreatic β-cell function is inhibited by miR-3666 in type 2 diabetes mellitus by targeting adiponectin

Oxiracetam ameliorates cognitive deficits in vascular dementia rats by regulating the expression of neuronal apoptosis/autophagy-related genes associated with the activation of the Akt/mTOR signaling pathway

The ERBB2 gene polymorphisms rs2643194, rs2934971, and rs1058808 are associated with increased risk of gastric cancer

Small RNA sequencing reveals microRNAs related to neuropathic pain in rats

FSH receptor binding inhibitor up-regulates ARID1A and PTEN genes associated with ovarian cancers in mice

Schizandrin A exerts anti-tumor effects on A375 cells by down-regulating H19

Chlorophyll treatment combined with photostimulation increases glycolysis and decreases oxidative stress in the liver of type 1 diabetic rats

Short-term creatine supplementation changes protein metabolism signaling in hindlimb suspension

Effects of natural aging and gender on pro-inflammatory markers

Clinical efficacy of tirofiban combined with a Solitaire stent in treating acute ischemic stroke

Downregulation of lncRNA CCDC26 contributes to imatinib resistance in human gastrointestinal stromal tumors through IGF-1R upregulation

Validation of the two-minute step test in obese with comorbibities and morbidly obese patients

Benzyl isothiocyanate inhibits invasion and induces apoptosis via reducing S100A4 expression and increases PUMA expression in oral squamous cell carcinoma cells

Skp2 inhibitor SKPin C1 decreased viability and proliferation of multiple myeloma cells and induced apoptosis

Association between elevated adiponectin level and adverse outcomes in patients with heart failure: a systematic review and meta-analysis

Thyroid disorders in Brazil: the contribution of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice

Age-related changes and effects of regular low-intensity exercise on gait, balance, and oxidative biomarkers in the spinal cord of Wistar rats

Carotid intima-media thickness and plaques in internal carotid artery as surrogate markers of lower limb arterial lesions in Chinese patients with diabetic foot

Baicalin ameliorates chronic mild stress-induced depression-like behaviors in mice and attenuates inflammatory cytokines and oxidative stress

Behavioral effects of Bj-PRO-7a, a proline-rich oligopeptide from Bothrops jararaca venom

Association between BDNF G196A (Val66Met) polymorphism and cognitive impairment in patients with Parkinson's disease: a meta-analysis

Pulmonary vein parameters are similar or better predictors than left atrial diameter for paroxysmal atrial fibrillation after cryoablation

Retrospective analysis of efficacy, safety, and prognostic factors in a cohort of Chinese hepatocellular carcinoma patients treated with drug-eluting bead transarterial chemoembolization

Effect of laser treatment on postural control parameters in patients with chronic nonspecific low back pain: a randomized placebo-controlled trial

Prevalence of ERG expression and PTEN loss in a Brazilian prostate cancer cohort

Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats

Two new mixed-ligand coordination polymers based on multi-N chelating ligand inhibit YAP expression and induce caspase-mediated spinal tumor cell apoptosis

Ventilation distribution as a contributor to the functional exercise capacity in patients with systemic sclerosis-associated interstitial lung disease without pulmonary hypertension

Recurrent hepatitis C treatment with direct acting antivirals – a real life study at a Brazilian liver transplant center

Gene expression profiling reveals upregulated FUT1 and MYBPC1 in children with pancreaticobiliary maljunction

Effect of intraoperative lung-protective mechanical ventilation on pulmonary oxygenation function and postoperative pulmonary complications after laparoscopic radical gastrectomy

[RETRACTED ARTICLE] Ginsenoside Rd inhibits IL-1β-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination

Retraction notice for: “Ginsenoside Rd inhibits IL-1β-induced inflammation and degradation of intervertebral disc chondrocytes by increasing IL1RAP ubiquitination” [Braz J Med Biol Res (2019) 52(9): e8525]

A newly designed intensive caregiver education program reduces cognitive impairment, anxiety, and depression in patients with acute ischemic stroke

Association between MCP-1 -2518A>G polymorphism and asthma susceptibility: a meta-analysis

The E3 ligase MuRF2 plays a key role in the functional capacity of skeletal muscle fibroblasts

Correlation of ultrasonography synovitis with disease activity and clinical response to etanercept treatment in juvenile idiopathic arthritis patients

Local dermal application of a compound lidocaine cream in pain management of cancer wounds

Effects of physical exercise on skeletal muscles of rats with cerebral ischemia

Analysis of different levels of positive end-expiratory pressure during lung retrieval for transplantation: an experimental study

Expression of myo-inositol cotransporters in the sciatic nerve and dorsal root ganglia in experimental diabetes

Are experienced and high-level race walking athletes able to match pre-programmed with executed pacing?

Sepsis: evolving concepts and challenges

Comparison of three PET methods to assess peritoneal membrane transport

Enhancement of cellular activity in hyperglycemic mice dermal wounds dressed with chitosan-alginate membranes

lncRNA MEG3 inhibits the growth of hepatocellular carcinoma cells by sponging miR-9-5p to upregulate SOX11

Feasibility of non-intubated anesthesia and regional block for thoracoscopic surgery under spontaneous respiration: a prospective cohort study

Use of flash glucose-sensing technology in patients with type 2 diabetes treated with liraglutide combined with CSII: a pilot study

Upregulation of miR-129-5p increases the sensitivity to Taxol through inhibiting HMGB1-mediated cell autophagy in breast cancer MCF-7 cells

Interleukin-6 and adhesion molecules VCAM-1 and ICAM-1 as biomarkers of post-acute myocardial infarction heart failure

CCR3 antagonist impairs estradiol-induced eosinophil migration to the uterus in ovariectomized mice

Effect of fasudil on experimental autoimmune neuritis and its mechanisms of action

Decreased respiratory performance of children and adolescents with myelomeningocele who use a wheelchair – preliminary data

Does whole body vibration exercise improve oxidative stress markers in women with fibromyalgia?

Reproducibility of carotid ultrasound measurements in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) at baseline

Ca2+/Calmodulin-dependent kinase II delta B is essential for cardiomyocyte hypertrophy and complement gene expression after LPS and HSP60 stimulation in vitro

Exosomes secreted from miRNA-29b-modified mesenchymal stem cells repaired spinal cord injury in rats

Beneficial effects of Cuscuta chinensis extract on glucocorticoid-induced osteoporosis through modulation of RANKL/OPG signals

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Serum regucalcin is a useful indicator of liver injury severity in patients with hepatitis B virus-related liver diseases

Content Provider	Scientific Electronic Library Online (SciELO)
Author	Wei, Xinhuan Yu, Haibin Zhao, Peng Xie, Li Li, Li Zhang, Jing
Abstract	Regucalcin is a soluble protein that is principally expressed in hepatocytes. Studies of regucalcin have mainly been conducted in animals due to a lack of commercially available kits. We aimed to develop an enzyme-linked immunosorbent assay (ELISA) to quantify serum regucalcin in patients with hepatitis B virus (HBV)-related disease. High-titer monoclonal antibodies and a polyclonal antibody to regucalcin were produced, a double-antibody sandwich ELISA method was established, and serum regucalcin was determined in 47 chronic hepatitis B (CHB) patients, 91 HBV-related acute-on-chronic liver failure (HBV-ACLF) patients, and 33 healthy controls. The ELISA demonstrated an appropriate linear range, and high levels of reproducibility, sensitivity, specificity, accuracy, and stability. The median serum regucalcin concentrations in HBV-ACLF and CHB patients were 5.46 and 3.76 ng/mL, respectively (P<0.01), which were much higher than in healthy controls (1.72 ng/mL, both P<0.01). For the differentiation of CHB patients and healthy controls, the area under curve (AUC) was 0.86 with a cut-off of 2.42 ng/mL, 85.7% sensitivity, and 78.8% specificity. In contrast, the AUC of alanine aminotransferase (ALT) was lower (AUC=0.80, P=0.01). To differentiate ACLF from CHB, the AUC was 0.72 with a cut-off of 4.26 ng/mL, 77.0% sensitivity, and 61.2% specificity while the AUC of ALT was 0.41 (P=0.07). Thus, we have developed an ELISA that is suitable for measuring serum regucalcin and have shown that serum regucalcin increased with the severity of liver injury due to HBV-related diseases, such that it appears to be more useful than ALT as a marker of liver injury.
Related Links	http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-879X2019001000605&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001000605&lng=en&nrm=iso
File Format	PDF
ISSN	01008790
DOI	10.1590/1414-431x20198845
Journal	Brazilian Journal of Medical and Biological Research
Issue Number	10
Volume Number	52
Language	English
Publisher	Associação Brasileira de Divulgação Científica
Publisher Date	2019-01-01
Access Restriction	Open
Subject Keyword	Regucalcin Liver injury Chronic hepatitis B infection ELISA Liver failure
Content Type	Text
Resource Type	Article

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