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| Content Provider | Scientific Electronic Library Online (SciELO) |
|---|---|
| Author | MOGHMI, Mansour ARJMANDI, Amir AGHILI, Kazem JAFARI, Mohammadali ZARE-SHEHNEH, Masoud RASTEGAR, Shohreh ABOLBAGHAEI, Seyed Mojtaba NEAMATZADEH, Hossein |
| Abstract | ABSTRACT Introduction: A series of studies have evaluated the association between -592A>C and -819T>C polymorphisms in the promoter regions of Interleukin-10 (IL-10) and gastric cancer (GC) risk. However, the results remain inconclusive. Objective: To better understand the association of the polymorphisms with GC risk, we performed a comprehensive meta-analysis. Method: An electronic search was performed of several databases to identify relevant studies up to April 2018. Results: A total of 44 case-control studies, including 26 studies on IL-10 -592A>C (5,332 cases and 8,272 controls) and 18 studies on IL-10 -819T>C (3,431 cases and 6,109 controls) were selected. Overall, -592A>C polymorphism was associated with the risk of GC under the heterozygote model (OR=1.153, 95% CI=1.020-1.305, p=0.023), but not -819T>C polymorphism. When stratified by ethnicity, significant association was only observed in the Asians under the allele model (OR=1.153, 95% CI=1.007-1.320, p=0.040) and the heterozygote model (OR=1.218, 95% CI=1.076-1.379, p=0.002) for -592A>C. Conclusion: The current meta-analysis results inconsistent with previous meta-analyses; showed that the IL-10 -592A>C polymorphism, but not -819T>C polymorphism, may be contributed to the susceptibility of GC in overall and Asian populations. |
| Related Links | http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-67202019000100500&lng=en&nrm=iso http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202019000100500&lng=en&nrm=iso |
| File Format | |
| ISSN | 01026720 |
| DOI | 10.1590/0102-672020180001e1415 |
| Journal | ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) |
| Issue Number | 1 |
| Volume Number | 32 |
| Language | English Portuguese |
| Publisher | Colégio Brasileiro de Cirurgia Digestiva |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Stomach neoplasms Interleukin-10 Polymorphism, genetic Meta-analysis Neoplasias Gástricas Interleucina-10 Polimorfismo genético Metanálise |
| Alternative Title | ASSOCIAÇÃO DE POLIMORFISMOS DA INTERLEUCINA-10 -592A>C E -819T>C COM RISCO DE CÂNCER GÁSTRICO: REVISÃO SISTEMÁTICA E METANÁLISE DE 44 ESTUDOS DE CASO-CONTROLE |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology Surgery |
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