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Factors Influencing Short-term Synaptic Plasticity in the Avian Cochlear Nucleus Magnocellularis
| Content Provider | SAGE Publishing |
|---|---|
| Author | Jason Tait Sanchez Quinones Karla, Quinones Sebastian, Otto-Meyer |
| Copyright Year | 2015 |
| Abstract | Defined as reduced neural responses during high rates of activity, synaptic depression is a form of short-term plasticity important for the temporal filtering of sound. In the avian cochlear nucleus magnocellularis (NM), an auditory brainstem structure, mechanisms regulating short-term synaptic depression include pre-, post-, and extrasynaptic factors. Using varied paired-pulse stimulus intervals, we found that the time course of synaptic depression lasts up to four seconds at late-developing NM synapses. Synaptic depression was largely reliant on exogenous Ca2+-dependent probability of presynaptic neurotransmitter release, and to a lesser extent, on the desensitization of postsynaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor (AMPA-R). Interestingly, although extrasynaptic glutamate clearance did not play a significant role in regulating synaptic depression, blocking glutamate clearance at early-developing synapses altered synaptic dynamics, changing responses from depression to facilitation. These results suggest a developmental shift in the relative reliance on pre-, post-, and extrasynaptic factors in regulating short-term synaptic plasticity in NM. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.4137/JEN.S25472?download=true |
| ISSN | 26331055 |
| Volume Number | 9s2 |
| Journal | Journal of Experimental Neuroscience (EXN) |
| e-ISSN | 26331055 |
| DOI | 10.4137/JEN.S25472 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2015-10-22 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © 2015 SAGE Publications. |
| Subject Keyword | glutamate transporters desensitization AMPA receptors development nucleus magnocellularis short-term synaptic depression |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
