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Current and Emerging Pharmacotherapies for the Treatment of Relapsed Small Cell Lung Cancer
| Content Provider | SAGE Publishing |
|---|---|
| Author | Nair, Binu S. Bhanderi, Vipul Jafri, Syed H. |
| Copyright Year | 2011 |
| Abstract | Small cell lung cancer (SCLC) is a very aggressive cancer with poor outcome if left untreated, but it is also one of the most chemotherapy responsive cancers. Overall it has a very poor prognosis especially if it is chemotherapy resistant to first line treatment. Second line chemotherapy has not been very beneficial in SCLC as opposed to breast cancer and lymphoma. In the last few years topotecan is the only drug that has been approved by the food and drug administration (FDA) for the second line treatment of SCLC but in Japan another drug, amrubicin is approved. There are many combinations of different chemotherapies available in moderate to high intensity, in this difficult to treat patient to overcome the chemo resistance, but many of these studies are small or phase II trials. In this article we have reviewed single agent and multidrug regimens that were studied in both chemo sensitive and refractory setting, including the most recent clinical trials. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.4137/CMO.S5964?download=true |
| ISSN | 11795549 |
| Volume Number | 5 |
| Journal | Clinical Medicine Insights: Oncology (ONC) |
| e-ISSN | 11795549 |
| DOI | 10.4137/CMO.S5964 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2011-07-25 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © 2011 SAGE Publications. |
| Subject Keyword | relapsed small cell lung cancer refractory topotecan amrubicin |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
