NDLI: Transcriptome Analysis of Minimal Residual Disease in Subtypes of Pediatric B Cell Acute Lymphoblastic Leukemia

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Transcriptome Analysis of Minimal Residual Disease in Subtypes of Pediatric B Cell Acute Lymphoblastic Leukemia

Content Provider	SAGE Publishing
Author	Sitthi-Amorn, Jitsuda Herrington, Betty Megason, Gail Pullen, Jeanette Gordon, Catherine Hogan, Shirley Koganti, Tejaswi Hicks, Chindo
Copyright Year	2015
Abstract	Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and the leading cause of cancer-related death in children and adolescents. Minimal residual disease (MRD) is a strong, independent prognostic factor. The objective of this study was to identify molecular signatures distinguishing patients with positive MRD from those with negative MRD in different subtypes of ALL, and to identify molecular networks and biological pathways deregulated in response to positive MRD at day 46. We compared gene expression levels between patients with positive MRD and negative MRD in each subtype to identify differentially expressed genes. Hierarchical clustering was applied to determine their functional relationships. We identified subtype-specific gene signatures distinguishing patients with positive MRD from those with negative MRD. We identified the genes involved in cell cycle, apoptosis, transport, and DNA repair. We also identified molecular networks and biological pathways dysregulated in response to positive MRD, including Granzyme B, B-cell receptor, and PI3K signaling pathways.
Related Links	https://journals.sagepub.com/doi/pdf/10.4137/CMO.S17049?download=true
ISSN	11795549
Volume Number	9
Journal	Clinical Medicine Insights: Oncology (ONC)
e-ISSN	11795549
DOI	10.4137/CMO.S17049
Language	English
Publisher	Sage Publications UK
Publisher Date	2015-05-24
Publisher Place	London
Access Restriction	Open
Rights Holder	© 2015 SAGE Publications.
Subject Keyword	B-cell acute lymphoblastic leukemia minimal residual disease gene expression
Content Type	Text
Resource Type	Article
Subject	Oncology

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Transcriptome Analysis of Minimal Residual Disease in Subtypes of Pediatric B Cell Acute Lymphoblastic Leukemia

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