NDLI: Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker

Content Provider	SAGE Publishing
Author	Filntisi, Arianna Vlachakis, Dimitrios Matsopoulos, George K. Kossida, Sophia
Copyright Year	2014
Abstract	Antibody-drug conjugates (ADCs) constitute a category of anticancer targeted therapy that has gathered great interest during the last few years because of their potential to kill cancer cells while causing significantly fewer side effects than traditional chemotherapy. In this paper, a process of computational construction of ADCs is described, using the surface lysines of an antibody and a non-covalent linker molecule, as well as a cytotoxic substance, as files in Protein Data Bank format. Also, aspects related to the function, properties, and development of ADCs are discussed.
Related Links	https://journals.sagepub.com/doi/pdf/10.4137/CIN.S19222?download=true
ISSN	11769351
Volume Number	13
Journal	Cancer Informatics (CIX)
e-ISSN	11769351
DOI	10.4137/CIN.S19222
Language	English
Publisher	Sage Publications UK
Publisher Date	2014-12-08
Publisher Place	London
Access Restriction	Open
Rights Holder	© 2014 SAGE Publications.
Subject Keyword	targeted therapy cancer antibody-drug conjugate
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker