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The MUC1 Cytoplasmic Tail and Tandem Repeat Domains Contribute to Mammary Oncogenesis in FVB Mice
| Content Provider | SAGE Publishing |
|---|---|
| Author | Hattrup, Christine L. Bradley, Judy M. Kotlarczyk, Kari L. Madsen, Cathy S. Hentz, Joseph G. Marler, Ronald J. Gendler, Sandra J. |
| Copyright Year | 2008 |
| Abstract | Though the importance of the transmembrane mucin MUC1 in mammary oncogenesis has long been recognized, the relative contributions of the cytoplasmic tail and tandem repeat domains are poorly understood.MethodsTo address this, mouse models of mammary carcinogenesis were created expressing full-length cytoplasmic tail-deleted, or tandem repeat-deleted MUC1 constructs.ResultsOverexpression of full-length MUC1 resulted in tumor formation in young mice (≤ 12 months); however, loss of either the cytoplasmic tail or the tandem repeat domain abrogated this oncogenic capacity. Aged mice in all strains developed late-onset mammary tumors similar to those previously described for the FVB background.ConclusionsThis study is the first spontaneous cancer model to address the relative importance of the cytoplasmic tail and tandem repeat domains to MUC1-driven mammary oncogenesis, and suggests that both of these domains are essential for tumor formation. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.4137/BCBCR.S655?download=true |
| ISSN | 11782234 |
| Volume Number | 1 |
| Journal | Breast Cancer: Basic and Clinical Research (BCB) |
| e-ISSN | 11782234 |
| DOI | 10.4137/BCBCR.S655 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2008-04-17 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © 2008 SAGE Publications. |
| Subject Keyword | breast cancer mouse models tandem repeat mucin MUC1 cytoplasmic tail |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
