Loading...
Please wait, while we are loading the content...
Similar Documents
Proliferative Diabetic Retinopathy Events in Patients With Diabetic Macular Edema: Post Hoc Analysis of VISTA and VIVID Trials
| Content Provider | SAGE Publishing |
|---|---|
| Author | Do, Diana V. Gordon, Carmelina Suñer, Ivan J. Reed, Kimberly Moini, Hadi Gibson, Andrea Du, Weiming Shah, Chirag P. |
| Copyright Year | 2022 |
| Abstract | This work aimed to assess the incidence of proliferative diabetic retinopathy (PDR) events and improvement to mild non-PDR (NPDR) or better after intravitreal aflibercept injection (IAI) or laser treatment (control) in diabetic macular edema (DME).Methods:PDR events in the VISTA (NCT01363440) and VIVID (NCT01331681) phase 3 clinical trials were evaluated in a combined IAI-treated group (IAI 2 mg every 4 weeks or 2 mg every 8 weeks after 5 initial monthly doses; n = 475) and a macular laser control group (n = 235) through week 100 in eyes without PDR at baseline (Diabetic Retinopathy Severity Scale [DRSS] score ≤ 53). Improvement in the DRSS score to 35 or better was evaluated in those with a baseline DRSS score of 43 or greater.Results:A lower proportion of eyes in the IAI group than in the laser group developed a PDR event through week 100 (4.4% vs 11.1%; adjusted difference, −6.7%; 97.5% CI, −11.7 to −1.6; nominal P = .0008). All PDR events occurred in eyes with a baseline DRSS score of 43, 47, or 53 and not in those with a score of 35 or less. A greater proportion of eyes in the IAI group than in the control group achieved a DRSS score of 35 or less (20.0% vs 3.8%; nominal P < .0001).Conclusions:Fewer eyes with NPDR and DME treated with IAI than eyes treated with a laser had a PDR event. More eyes treated with IAI improved to mild NPDR or better (DRSS score ≤ 35) through 100 weeks. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/24741264221093914?download=true |
| Starting Page | 295 |
| Ending Page | 301 |
| Page Count | 7 |
| ISSN | 24741264 |
| Issue Number | 4 |
| Volume Number | 6 |
| Journal | Journal of VitreoRetinal Diseases (VRD) |
| e-ISSN | 24741272 |
| DOI | 10.1177/24741264221093914 |
| Language | English |
| Publisher | Sage Publications CA |
| Publisher Date | 2022-06-04 |
| Publisher Place | Los Angeles |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2022 |
| Subject Keyword | diabetic macular edema anti-VEGF therapy VISTA proliferative diabetic retinopathy VIVID intravitreal aflibercept diabetic retinopathy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
