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Short- to Midterm Clinical and Radiological Outcomes After Matrix-Associated Autologous Chondrocyte Implantation for Chondral Defects in Knees
| Content Provider | SAGE Publishing |
|---|---|
| Author | Dai, Xuesong Fang, Jinghua Wang, Siheng Luo, Jianyang Xiong, Yan Zhang, Miaofeng Zhu, Sunan Yu, Xinning |
| Copyright Year | 2021 |
| Abstract | Matrix-associated autologous chondrocyte implantation (MACI) has been proven to provide favorable short-term results for chondral defects in knees. However, it remains unclear whether the clinical benefits of MACI persist in the longer term.Purpose:The purpose of this prospective study was to evaluate the clinical and radiological outcomes, at short- and midterm follow-up, for patients undergoing MACI for focal chondral defects of the knee.Study Design:Case series; Level of evidence, 4.Methods:A total of 30 consecutive patients (31 knees) were treated using MACI between October 2010 and March 2018. There were 24 male patients and 6 female patients with an average age of 26 years (range, 12-48 years). The areas of the cartilage defect were consistently >2 cm2. All patients underwent MACI for a focal chondral defect of the femoral condyles or trochlea in the knee. These patients had been evaluated for up to 5 years, with an average follow-up of 44 months (range, 6-60 months) postoperatively.The International Knee Documentation Committee (IKDC) score, Lysholm score, and magnetic resonance imaging (MRI) with T2 mapping were used to assess the outcomes.Results:No patients were lost to follow-up. Mean IKDC scores improved from 58.6 (range, 40.2-80.5) to 79.1 (range, 39.1-94.3) at 12 months and up to 88.4 (range, 83.9-100) at 5 years; mean Lysholm scores improved from 67.3 (range, 46-95) to 90.6 (range, 71-100) at 12 months and up to 95.9 (range, 85-100) at 5 years. The MRI with T2 mapping value of the transplanted area was evaluated for 21 knees, which revealed no differences compared with the normal area at 12 months postoperatively.Conclusion:From the first year onward, the clinical outcome scores and MRI with T2 mapping values showed continuous and marked improvement, suggesting that MACI is a valid option for localized cartilage defects in the knee. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/2325967120982139?download=true |
| ISSN | 23259671 |
| Issue Number | 2 |
| Volume Number | 9 |
| Journal | Orthopaedic Journal of Sports Medicine (OJS) |
| e-ISSN | 23259671 |
| DOI | 10.1177/2325967120982139 |
| Language | English |
| Publisher | Sage Publications CA |
| Publisher Date | 2021-02-24 |
| Publisher Place | Los Angeles |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2021 |
| Subject Keyword | knee biologic healing enhancement matrix-induced autologous chondrocyte implantation articular cartilage biology of cartilage clinical assessment/grading scales |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine |
