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Use of Phenobarbital in Delirium Tremens
| Content Provider | SAGE Publishing |
|---|---|
| Author | Fujimoto, Jeffrey Lou, Jerry J. Pessegueiro, Antonio M. |
| Copyright Year | 2017 |
| Abstract | The standard of care for alcohol withdrawal centers on the use of escalating doses of benzodiazepines until clinical improvement is achieved. However, there is no established standard in the care of patients with severe alcohol withdrawal and delirium tremens that is refractory to benzodiazepine therapy. One potential therapy that is gaining traction is the use of phenobarbital, which may be mechanistically superior to benzodiazepines in treating delirium tremens because of its effects on GABA and N-methyl-D-aspartate receptors. The dosing of phenobarbital and its subsequent taper, however, is still unclear and the side effect profile is not well characterized. In this case report, we present the case of a 37-year-old Hispanic male who presented with alcohol withdrawal and subsequent delirium tremens who was treated with phenobarbital with positive clinical response and minimal side effects. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/2324709617742166?download=true |
| ISSN | 23247096 |
| Issue Number | 4 |
| Volume Number | 5 |
| Journal | Journal of Investigative Medicine High Impact Case Reports (HIC) |
| e-ISSN | 23247096 |
| DOI | 10.1177/2324709617742166 |
| Language | English |
| Publisher | Sage Publications CA |
| Publisher Date | 2017-11-13 |
| Publisher Place | Los Angeles |
| Access Restriction | Open |
| Rights Holder | © 2017 American Federation for Medical Research |
| Subject Keyword | phenobarbital barbiturates alcohol withdrawal alcohol abuse delirium tremens benzodiazepines |
| Content Type | Text |
| Resource Type | Article |
| Subject | Safety Research Safety, Risk, Reliability and Quality Epidemiology |
