NDLI: Fabrication of pH-sensitive graphene oxide–Benazepril carrier as biosafety controlled release systems

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Fabrication of pH-sensitive graphene oxide–Benazepril carrier as biosafety controlled release systems

Content Provider	SAGE Publishing
Author	Liu, Tianxiong Li, Yujiao Chen, Xianzhe Zhao, Xiaoming Wang, Jianfang Zhang, Dongyi
Copyright Year	2020
Abstract	A novel graphene oxide (GO)-based carrier was fabricated for the controlled release of Benazepril (BENA). Freeze dried samples of GO–BENA carrier were prepared for controlled drug release at different pHs (pH = 2, 7, and 10) and release kinetics indicate BENA desorption from GO is by Fickian diffusion. The BENA yield from the carrier amounted to ~55% of the adsorbed material in a strongly acidic medium after 50 h. Binding fractions of BENA to 10 mg/L GO was determined for different solution concentrations of the drug. In vitro assays of cell proliferation (WST-1 kit), cell structural integrity (LDH kit) and flow cytometric indicators of necrosis in three different cell lines (CACO-2, SGC-7901, and primary mouse hepatic fibroblast) all demonstrated that the GO carrier had a good biocompatibility. The pH-dependent release sensitivity of the GO-based carrier suggests that it is a potential candidate for use in the controlled release of drugs in the acidic environment of the stomach.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/2280800020963471?download=true
ISSN	22808000
Volume Number	18
Journal	Journal of Applied Biomaterials & Functional Materials (JBF)
e-ISSN	22808000
DOI	10.1177/2280800020963471
Language	English
Publisher	Sage Publications UK
Publisher Date	2020-12-03
Publisher Place	London
Access Restriction	Open
Rights Holder	© The Author(s) 2020
Subject Keyword	Benazepril biosafety Graphene oxide drug carrier controlled release
Content Type	Text
Resource Type	Article
Subject	Medicine Biomaterials Biophysics Bioengineering Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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