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A comparison of low-dose teicoplanin-loaded spacer application vs. high-dose vancomycin-and-gentamicin-loaded spacer application in the treatment of periprosthetic knee infection
| Content Provider | SAGE Publishing |
|---|---|
| Author | Cimen, Osman Oner, Ali Koksal, Alper Dırvar, Ferdi Mert, Muhammed Şahin, Mümine Nursu Kargın, Deniz |
| Copyright Year | 2022 |
| Abstract | Background/purposeIn the current study, our aim was to compare the efficacy and biocompatibility of teicoplanin-loaded and vancomycin-and-gentamicin-loaded articulating spacers used in two-stage revision arthroplasty for eradication of periprosthetic knee joint infection.MethodsIn the current retrospective cohort study, there were 24 patients who were given 2 g or less antibiotics per 40 g of cement in the low-dose teicoplanin group, and 20 patients who were given a total of 3.6 g or more antibiotics per 40 g of cement in the high-dose vancomycin and gentamicin group. Two groups were compared statistically.ResultsThere was no statistically significant difference in the treatment failure between the two groups (p = 0.488). No statistically significant differences were found in spacer fracture rates between the two groups (p = 0.802).ConclusionThe current study has demonstrated that low-dose teicoplanin protocol is as effective and safe as high-dose vancomycin and gentamycin protocol. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/22104917221082312?download=true |
| ISSN | 22104917 |
| Issue Number | 1 |
| Volume Number | 29 |
| Journal | Journal of Orthopaedics, Trauma and Rehabilitation (OTR) |
| e-ISSN | 22104925 |
| DOI | 10.1177/22104917221082312 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2022-04-13 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2022 |
| Subject Keyword | gentamicin periprosthetic joint infection teicoplanin vancomycin Antibiotic loaded spacer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Orthopedics and Sports Medicine Rehabilitation Physical Therapy, Sports Therapy and Rehabilitation |
