NDLI: Which Fecal Immunochemical Test Should I Choose?

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Which Fecal Immunochemical Test Should I Choose?

Content Provider	SAGE Publishing
Author	Daly, Jeanette M. Xu, Yinghui Levy, Barcey T.
Copyright Year	2017
Abstract	To summarize the fecal immunochemical tests (FITs) available in the United States, the 2014 pathology proficiency testing (PT) program FIT results, and the literature related to the test characteristics of FITs available in the United States to detect advanced adenomatous polyps (AAP) and/or colorectal cancer (CRC). Methods: Detailed review of the Food and Drug Administration’s Clinical Laboratory Improvement Amendments (CLIA) database of fecal occult blood tests, the 2014 FIT PT program results, and the literature related to FIT accuracy. Results: A search of the CLIA database identified 65 FITs, with 26 FITs available for purchase in the United States. Thirteen of these FITs were evaluated on a regular basis by PT programs, with an overall sensitivity of 99.1% and specificity of 99.2% for samples spiked with hemoglobin. Automated FITs had better sensitivity and specificity than CLIA-waived FITs for detection of AAP and CRC in human studies using colonoscopy as the gold standard. Conclusion: Although many FITs are available in the United States, few have been tested in proficiency testing programs. Even fewer have data in humans on sensitivity and specificity for AAP or CRC. Our review indicates that automated FITs have the best test characteristics for AAP and CRC.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/2150131917705206?download=true
Starting Page	264
Ending Page	277
Page Count	14
ISSN	21501319
Issue Number	4
Volume Number	8
Journal	Journal of Primary Care & Community Health (JPC)
e-ISSN	21501327
DOI	10.1177/2150131917705206
Language	English
Publisher	Sage Publications CA
Publisher Date	2017-04-27
Publisher Place	Los Angeles
Access Restriction	Open
Rights Holder	© The Author(s) 2017
Subject Keyword	fecal occult blood test health promotion colorectal cancer screening fecal immunochemical test proficiency testing programs
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health Community and Home Care

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