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The significance of M1/M2 macrophage-like monocytes in children with systemic lupus erythematosus
| Content Provider | SAGE Publishing |
|---|---|
| Author | Niu, Xiao-Ling Feng, Dan Hao, Sheng Kuang, Xin-Yu Wu, Ying Zhu, Guang-Hua Huang, Wen-Yan |
| Copyright Year | 2019 |
| Abstract | Monocytes/macrophages are important in the development of systemic lupus erythematosus. To research M1 and M2 macrophage-like monocytes in the peripheral blood of children with systemic lupus erythematosus and explore the clinical significance, M1 and M2 macrophage-like monocytes, tumor necrosis factor-α, interleukin-1, interleukin-6, interleukin-10, and interleukin-18 are tested in the peripheral blood of children with systemic lupus erythematosus by flow cytometry. A correlation analysis is made between M1 and M2 macrophage-like monocytes and erythrocyte sedimentation rate and C-reactive protein. As we found, the absolute number and percentage of M1 macrophage-like monocytes (CD163–CD14+) in macrophage-like monocytes (CD14+) in peripheral blood of the severe systemic lupus erythematosus group were higher than those of the control group and the mild–moderate systemic lupus erythematosus group (F = 28.4, 21.7, 122, 81.7; P < 0.05). But there was no obvious difference between these three groups in terms of the absolute number of M2 macrophage-like monocytes (CD163+CD14+). The absolute number and percentage of M1 macrophage-like monocytes in macrophage-like monocytes had positive correlation with C-reactive protein and erythrocyte sedimentation rate (r = 0.46, 0.44, 0.367, 0.47; P < 0.05); whereas, the absolute number and percentage of M2 macrophage-like monocytes in macrophage-like monocytes had negative correlation with CRP and erythrocyte sedimentation rate (r = –0.47, –0.45, –0.47, –0.32; P < 0.05). Thus, M1 macrophage-like monocytes have effective impact on inflammation in children with systemic lupus erythematosus. M2 macrophage-like monocytes, to a large extent, have the opposite functions compared to M1 macrophage-like monocytes. In children with systemic lupus erythematosus, macrophages play important role in the development of systemic lupus erythematosus and M1 macrophage-like monocytes have functions in active systemic lupus erythematosus and they can induce the inflammation and have correlation with severity of systemic lupus erythematosus. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/2058739218824463?download=true |
| ISSN | 1721727X |
| Volume Number | 17 |
| Journal | European Journal of Inflammation (EJI) |
| e-ISSN | 20587392 |
| DOI | 10.1177/2058739218824463 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2019-01-23 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2019 |
| Subject Keyword | monocytes/macrophages children systemic lupus erythematosus |
| Content Type | Text |
| Resource Type | Letter |
| Subject | Immunology and Allergy Immunology |
