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Spontaneous brain tumor imaging of aged rat by crystal X-ray interferometer-based phase-contrast X-ray CT

Content Provider	SAGE Publishing
Author	Lwin, Thet-Thet Yoneyama, Akio Hara, Atsuko Ohbu, Makoto Maruyama, Hiroko Taguchi, Masaya Esashi, Shogo Matsushima, Tsubasa Terazaki, Kei Hyodo, Kazuyuki Takeda, Tohoru
Copyright Year	2016
Abstract	Crystal X-ray interferometer-based phase-contrast X-ray computed tomography (C-PCCT) enables the depiction of internal structures of biological tissue without contrast agents.PurposeTo determine the advantage of this technique in visualizing detailed morphological structures of a rare spontaneous brain tumor in an aged rat.Material and MethodsAn aged rat’s spontaneous brain tumor was imaged by C-PCCT without contrast agent. Three-dimensional (3D) images of the tumor microvasculature were reconstructed and compared with pathological pictures.ResultsC-PCCT depicted the tumor’s various pathological features clearly, e.g. its cell density and vasculature, and blood clots caused by hemorrhaging and/or hematomas. The obtained images resembled pathological pictures with a magnification of ×20 and were used to reconstruct 3D images of the tumor vascularity up to approximately 26 µm in diameter.ConclusionSince C-PCCT is able to depict various pathological conditions, it might be useful for cancer research.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/2058460115626958?download=true
ISSN	20584601
Issue Number	2
Volume Number	5
Journal	Acta Radiologica Open (ARR)
e-ISSN	20584601
DOI	10.1177/2058460115626958
Language	English
Publisher	Sage Publications UK
Publisher Date	2016-02-15
Publisher Place	London
Access Restriction	Open
Rights Holder	© The Foundation Acta Radiologica 2016
Subject Keyword	spontaneous brain tumor Crystal X-ray interferometer-based phase-contrast X-ray CT (C-PCCT) aged rat computed tomography (CT)
Content Type	Text
Resource Type	Article

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