NDLI: Expression and clinical significance of the receptors of the EGF family in oral squamous cell carcinomas

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Expression and clinical significance of the receptors of the EGF family in oral squamous cell carcinomas

Content Provider	SAGE Publishing
Author	Dissanayake, Upul
Copyright Year	2019
Abstract	Objective:To examine the immunohistochemical expression of four members of the type 1 growth factor receptor family in oral squamous cell carcinomas (OSCCs) and to correlate with clinical outcomes.Materials and methods:Sixty OSCCs from a patient cohort in Sri Lanka were included in the study. Five sections from each carcinoma were immunostained with antibodies to epidermal growth factor receptor (EGFR)/c-erbB-1, c-erbB-2/HER-2/neu, c-erbB-3/HER-3 and c-erbB-4/HER-4. Two clones were used to stain for c-erbB-2/HER-2/neu. Semiquantitative analysis of immunoreactivity was carried out by scoring the intensity of expression and proportions of positively stained cells. A logistic regression analysis was performed to examine positive expression against overall survival.Results:There was heterogenous expression of the four receptors, positivity ranging from 26% to 60%. Co-expression of all four markers was observed only in 1–3% of the tumours. Both membranous and cytoplasmic expressions were observed, EGFR showing predominantly membranous expression and c-erbB-2 showing only cytoplasmic staining. In logistic regression analysis, none of the growth factor receptors were significantly predictive of overall survival.Conclusion:Type 1 growth factor receptors are highly expressed in oral carcinomas, EGFR being the predominant marker.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/2057178X19836532?download=true
ISSN	2057178X
Volume Number	4
Journal	Translational Research in Oral Oncology (TOO)
e-ISSN	2057178X
DOI	10.1177/2057178X19836532
Language	English
Publisher	Sage Publications UK
Publisher Date	2019-03-27
Publisher Place	London
Access Restriction	Open
Rights Holder	© The Author(s) 2019
Subject Keyword	oral cancer c-erbB-2/HER-2/neu EGFR/c-erbB-1 c-erbB4/HER-4 survival Growth factor receptors squamous cell carcinoma c-erbB-3/HER-3
Content Type	Text
Resource Type	Article

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