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Static and group-based trajectory analyses of factors associated with non-adherence in patients with multiple sclerosis newly-initiating once- or twice-daily oral disease-modifying therapy
| Content Provider | SAGE Publishing |
|---|---|
| Author | Nicholas, Jacqueline A. Edwards, Natalie C. Edwards, Roger A. Dellarole, Anna Manca, Luigi Harlow, Danielle E. Phillips, Amy L. |
| Copyright Year | 2022 |
| Abstract | Increased understanding of adherence may facilitate optimal targeting of interventions.ObjectiveTo utilize group-based trajectory modeling (GBTM) to understand longitudinal patterns of adherence and factors associated with non-adherence in patients with multiple sclerosis (MS) newly-initiating once-/twice-daily oral disease-modifying therapy (DMT) (fingolimod, dimethyl fumarate, or teriflunomide).MethodsCommercial plan data were analyzed using proportion of days covered (PDC) to evaluate factors associated with non-adherence. GBTM clustered patient subgroups with similar longitudinal patterns of adherence measured by monthly PDC (≥80%) and multinomial logistic regression identified factors associated with adherence trajectory subgroups.ResultsAmong 7689 patients, 39.5% were non-adherent to once-/twice-daily oral DMTs. Characteristics associated with non-adherence (PDC<80%) included younger age, female, depression or migraine, switching during follow-up, more frequent dosing, relapse, and absence of magnetic resonance imaging. GBTM elucidated three adherence subgroups: Immediately Non-Adherent (14.9%); Gradually Non-Adherent (19.5%), and Adherent (65.6%). Additional factors associated with adherence (i.e. region, chronic lung disease) were identified and factors differed among trajectory subgroups.ConclusionThese analyses confirmed that a significant proportion of patients with MS are non-adherent to once-/twice-daily oral DMTs. Unique patterns of non-adherence and factors associated with patterns of adherence emerged. The approach demonstrated how quantitative trajectories can help clinicians develop tailored interventions. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/20552173221101150?download=true |
| ISSN | 20552173 |
| Issue Number | 2 |
| Volume Number | 8 |
| Journal | Multiple Sclerosis Journal – Experimental, Translational and Clinical (MSO) |
| e-ISSN | 20552173 |
| DOI | 10.1177/20552173221101150 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2022-06-30 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s), 2022 |
| Subject Keyword | non-adherence disease-modifying therapy Multiple sclerosis group-based trajectory modeling newly-initiating oral treatment |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) Cellular and Molecular Neuroscience |
