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Prediction of Progression in Polycystic Kidney Disease Using the Kidney Failure Risk Equation and Ultrasound Parameters
| Content Provider | SAGE Publishing |
|---|---|
| Author | Akbari, Ayub Tangri, Navdeep Brown, Pierre A. Biyani, Mohan Rhodes, Emily Kumar, Teerath Shabana, Wael Sood, Manish M. |
| Copyright Year | 2020 |
| Abstract | The kidney failure risk equation (KFRE) is a validated risk algorithm for predicting the risk of kidney failure in chronic kidney disease (CKD) patients regardless of etiology. Patients with autosomal dominant polycystic kidney disease (AD-PCKD) experience long disease trajectories and as such identifying individuals at risk of kidney failure would aid in interventionObjective:To examine the utility of the KFRE in predicting adverse kidney outcomes compared with existing risk factors in a cohort of patients with AD-PCKD.Methods:Retrospective cohort study of AD-PCKD patients referred to a tertiary care center with a baseline kidney ultrasound and a KFRE calculation. Cox proportional hazards were used to examine the association of the KFRE and composite of an eGFR decline of >30% or the need for dialysis/transplantation. Discrimination and calibration of a parsimonious fully adjusted model and a model containing only total kidney volume (TKV) with and without the addition of the KFRE was determined.Results:Of 340 patients with AD-PCKD eligible, 221 (65%) met inclusion criteria. Older age, cardiac disease, cancer, higher systolic blood pressure, albuminuria, lower eGFR and a higher initial TKV were more common in patients with a higher KFRE. A total of 120 events occurred over a median patient follow-up time of 3.2 years. KFRE was independently associated with the composite kidney outcome. Addition of the KFRE significantly improved discrimination and calibration in a TKV only model and a fully adjusted model.Conclusions:In a diverse, referral population with AD-PCKD, the KFRE was associated with adverse kidney outcomes and improved risk prediction. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/2054358120911274?download=true |
| ISSN | 20543581 |
| Volume Number | 7 |
| Journal | Canadian Journal of Kidney Health and Disease (CJK) |
| e-ISSN | 20543581 |
| DOI | 10.1177/2054358120911274 |
| Language | English |
| Publisher | Sage Publications CA |
| Publisher Date | 2020-03-18 |
| Publisher Place | Los Angeles |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2020 |
| Subject Keyword | AD-PKD (autosomal dominant polycystic disease) dialysis KFRE (kidney failure risk equation) CKD (chronic kidney disease) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nephrology |
