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Comparison of gadoxetic acid and gadopentetate dimeglumine-enhanced MRI for HCC detection: prospective crossover study at 3 T
| Content Provider | SAGE Publishing |
|---|---|
| Author | Besa, Cecilia Kakite, Suguru Cooper, Nancy Facciuto, Marcelo Taouli, Bachir |
| Copyright Year | 2015 |
| Abstract | Gadoxetic acid and gadopentetate dimeglumine are gadolinium-based contrast agents (GBCAs) with an established role in HCC detection and characterization.PurposeTo compare gadopentetate dimeglumine and gadoxetic acid-enhanced magnetic resonance imaging (MRI) for image quality and hepatocellular carcinoma (HCC) detection/conspicuity.Material and MethodsIn this IRB approved cross-over pilot prospective study, 12 patients (all men; mean age, 56 years) with chronic liver disease at risk of HCC underwent two repeat MRI examinations using gadopentetate dimeglumine and gadoxetic acid (mean interval between studies, 5 days). Two independent observers analyzed images for image quality and HCC detection/conspicuity. Per-lesion sensitivity, positive predictive value, quantitative enhancement, and lesion-to-liver contrast ratio were calculated for both contrast agents.ResultsThere was no significant difference in image quality scores between both GBCAs (P = 0.3). A total of 20 HCCs were identified with reference standard in 12 patients (mean size 2.6 cm, range, 1.0–5.0 cm). Higher sensitivity was seen for observer 1 for gadoxetic acid-set in comparison with gadopentetate dimeglumine-set (sensitivity increased from 85.7% to 92.8%), while no difference was noted for observer 2 (sensitivity of 78.5%). Lesion conspicuity was significantly higher on hepatobiliary phase (HBP) images compared to arterial phase images with both GBCAs for both observers (P < 0.05). Lesion-to-liver contrast ratios were significantly higher for HBP compared to all dynamic phases for both agents (P < 0.05).ConclusionOur initial experience suggests that gadoxetic acid-set was superior to gadopentetate dimeglumine-set in terms of HCC detection for one observer, with improved lesion conspicuity and liver-to-lesion contrast on HBP images. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/2047981614561285?download=true |
| ISSN | 20584601 |
| Issue Number | 2 |
| Volume Number | 4 |
| Journal | Acta Radiologica Open (ARR) |
| e-ISSN | 20584601 |
| DOI | 10.1177/2047981614561285 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2015-02-20 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Foundation Acta Radiologica 2015 |
| Subject Keyword | magnetic resonance imaging hepatocarcinoma Liver Gd-EOB-DTPA Gd-DTPA |
| Content Type | Text |
| Resource Type | Article |
