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Time to rehospitalization in involuntarily hospitalized individuals suffering from schizophrenia discharged on long-acting injectable antipsychotics or oral antipsychotics
| Content Provider | SAGE Publishing |
|---|---|
| Author | Lin, Ching-Hua Chan, Hung-Yu Wang, Fu-Chiang Hsu, Chun-Chi |
| Copyright Year | 2022 |
| Abstract | Involuntarily hospitalized individuals suffering from schizophrenia often have a poorer prognosis after discharge.Objective:This study aimed to analyze time to rehospitalization within 6 months of discharge in involuntarily hospitalized individuals suffering from schizophrenia discharged on long-acting injectable antipsychotics (LAIs) or oral antipsychotics (OAPs). In addition, temporal trends in LAI use at discharge were explored.Methods:Involuntarily hospitalized individuals suffering from schizophrenia discharged from the study hospital between 2006 and 2019 (n = 806) were included in the analysis. Survival analysis was used to compare time to rehospitalization within 6 months of discharge between individuals discharged on LAIs and OAPs, and between first-generation antipsychotic (FGA) LAIs and second-generation antipsychotic (SGA) LAIs. The Cochran–Armitage trend test was used to test whether a temporal trend existed for LAIs use at discharge during the study period.Results:The LAIs group (n = 231) had a significantly lower rate of rehospitalization and a significantly longer time to rehospitalization than the OAPs group (n = 575). Rehospitalization rate and time to rehospitalization were not significantly different between individuals discharged on FGA-LAIs and SGA-LAIs. LAIs use at discharge grew significantly from 16.77% in 2006 to 50.00% in 2019 (Z = 6.81, p < 0.0001). Among all LAIs, only use of SGA-LAIs at discharge increased significantly (Z = 5.74, p < 0.0001), but not FGA-LAIs.Conclusions:LAIs were superior to OAPs in preventing rehospitalization. However, SGA-LAIs were comparable with FGA-LAIs in reducing rehospitalization risk. Use of LAIs increased significantly in discharged involuntarily hospitalized individuals during the study period, especially SGA-LAIs. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/20451253221079165?download=true |
| ISSN | 20451253 |
| Volume Number | 12 |
| Journal | Therapeutic Advances in Psychopharmacology (TPP) |
| e-ISSN | 20451261 |
| DOI | 10.1177/20451253221079165 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2022-03-23 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s), 2022 |
| Subject Keyword | second-generation antipsychotics involuntary admission long-acting injectable antipsychotics schizophrenia rehospitalization |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Psychiatry and Mental Health |
