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The role of basal insulin and GLP-1 receptor agonist combination products in the management of type 2 diabetes
| Content Provider | SAGE Publishing |
|---|---|
| Author | Inman, Taylor R. Plyushko, Erika Austin, Nicholas P. Johnson, Jeremy L. |
| Copyright Year | 2018 |
| Abstract | The prevalence of type 2 diabetes necessitates the development of new treatment options to individualize therapy. Basal insulin has been a standard treatment option for years, while glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have grown in use over the past decade due to glucose-lowering efficacy and weight loss potential. There are two new combination injectable products that have recently been approved combining basal insulins with GLP-1 RAs in single pen-injector devices. United States guidelines recently emphasize the option to use combination injectable therapy with GLP-1 RAs and basal insulin once the basal insulin has been optimally titrated as a second- or third-line agent in addition to metformin without reaching the goal A1c. Insulin glargine/lixisenatide 100/33 (IGlarLixi) can be dosed between 15 and 60 units once daily from a single pen-injector device. Insulin degludec/liraglutide 100/3.6 (IDegLira) can be dosed between 10 and 50 units once daily, also from a single pen-injector device. Maximum doses, while measured in units, correspond to limits defined by each individual GLP-1 RA. The dual use of basal insulin plus GLP-1 RA is non-inferior compared with basal insulin plus a single injection of prandial insulin at the largest meal and compared with twice daily-dosed premixed insulins; and this combination is associated with weight loss and less hypoglycemia. These new combination products could help providers effectively and efficiently follow clinical practice guidelines while enhancing patient adherence with injectable medications. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/2042018818763698?download=true |
| Starting Page | 151 |
| Ending Page | 155 |
| Page Count | 5 |
| ISSN | 20420188 |
| Issue Number | 5 |
| Volume Number | 9 |
| Journal | Therapeutic Advances in Endocrinology and Metabolism (TAE) |
| e-ISSN | 20420196 |
| DOI | 10.1177/2042018818763698 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2018-04-23 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s), 2018 |
| Subject Keyword | degludec/liraglutide basal insulin glargine/lixisenatide type 2 diabetes combination injectable therapy IGlarLixi IDegLira GLP-1 receptor agonist |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology, Diabetes and Metabolism |
