NDLI: Development of stabilized dual growth factor-loaded hyaluronate collagen dressing matrix

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Development of stabilized dual growth factor-loaded hyaluronate collagen dressing matrix

Content Provider	SAGE Publishing
Author	Kim, Jihyun Lee, Kyoung-Mi Han, Seung Hwan Ko, Eun Ae Yoon, Dong Suk Park, Ik Kyu Shin, Hang-Cheol Park, Kwang Hwan Lee, Jin Woo
Copyright Year	2021
Abstract	Patients with diabetes experience impaired growth factor production such as epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF), and they are reportedly involved in wound healing processes. Here, we report dual growth factor-loaded hyaluronate collagen dressing (Dual-HCD) matrix, using different ratios of the concentration of stabilized growth factors—stabilized-EGF (S-EGF) and stabilized-bFGF (S-bFGF). At first, the optimal concentration ratio of S-EGF to S-bFGF in the Dual-HCD matrix is determined to be 1:2 in type I diabetic mice. This Dual-HCD matrix does not cause cytotoxicity and can be used in vivo. The wound-healing effect of this matrix is confirmed in type II diabetic mice. Dual HCD enhances angiogenesis which promotes wound healing and thus, it shows a significantly greater synergistic effect than the HCD matrix loaded with a single growth factor. Overall, we conclude that the Dual-HCD matrix represents an effective therapeutic agent for impaired diabetic wound healing.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/2041731421999750?download=true
ISSN	20417314
Volume Number	12
Journal	Journal of Tissue Engineering (TEJ)
e-ISSN	20417314
DOI	10.1177/2041731421999750
Language	English
Publisher	Sage Publications UK
Publisher Date	2021-03-16
Publisher Place	London
Access Restriction	Open
Rights Holder	© The Author(s) 2021
Subject Keyword	stabilized growth factor dual-hyaluronate collagen dressing matrix basic fibroblast growth factor Impaired wound healing epidermal growth factor
Content Type	Text
Resource Type	Article
Subject	Medicine Biomaterials Biomedical Engineering

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