NDLI: Decellularised scaffolds: just a framework? Current knowledge and future directions

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Decellularised scaffolds: just a framework? Current knowledge and future directions

Content Provider	SAGE Publishing
Author	García-Gareta, Elena Abduldaiem, Yousef Sawadkar, Prasad Kyriakidis, Christos Lali, Ferdinand Greco, Karin Vicente
Copyright Year	2020
Abstract	The use of decellularised matrices as scaffolds offers the advantage of great similarity with the tissue to be replaced. Moreover, decellularised tissues and organs can be repopulated with the patient’s own cells to produce bespoke therapies. Great progress has been made in research and development of decellularised scaffolds, and more recently, these materials are being used in exciting new areas like hydrogels and bioinks. However, much effort is still needed towards preserving the original extracellular matrix composition, especially its minor components, assessing its functionality and scaling up for large tissues and organs. Emphasis should also be placed on developing new decellularisation methods and establishing minimal criteria for assessing the success of the decellularisation process. The aim of this review is to critically review the existing literature on decellularised scaffolds, especially on the preparation of these matrices, and point out areas for improvement, finishing with alternative uses of decellularised scaffolds other than tissue and organ reconstruction. Such uses include three-dimensional ex vivo platforms for idiopathic diseases and cancer modelling.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/2041731420942903?download=true
ISSN	20417314
Volume Number	11
Journal	Journal of Tissue Engineering (TEJ)
e-ISSN	20417314
DOI	10.1177/2041731420942903
Language	English
Publisher	Sage Publications UK
Publisher Date	2020-07-22
Publisher Place	London
Access Restriction	Open
Rights Holder	© The Author(s) 2020
Subject Keyword	ECM acellular matrices cell seeding decellularisation Decellularised scaffolds tissue engineering
Content Type	Text
Resource Type	Article
Subject	Medicine Biomaterials Biomedical Engineering

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