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New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing
| Content Provider | SAGE Publishing |
|---|---|
| Author | Hoffmann, Andreas Leonards, Holger Tobies, Nora Pongratz, Ludwig Kreuels, Klaus Kreimendahl, Franziska Apel, Christian Wehner, Martin Nottrodt, Nadine |
| Copyright Year | 2017 |
| Abstract | Stereolithography is one of the most promising technologies for the production of tailored implants. Within this study, we show the results of a new resin formulation for three-dimensional printing which is also useful for subsequent surface functionalization. The class of materials is based on monomers containing either thiol or alkene groups. By irradiation of the monomers at a wavelength of 266 nm, we demonstrated an initiator-free stereolithographic process based on thiol-ene click chemistry. Specimens made from this material have successfully been tested for biocompatibility. Using Fourier-transform infrared spectrometry and fluorescent staining, we are able to show that off-stoichiometric amounts of functional groups in the monomers allow us to produce scaffolds with functional surfaces. We established a new protocol to demonstrate the opportunity to functionalize the surface by copper-catalyzed azide-alkyne cycloaddition chemistry. Finally, we demonstrate a three-dimensional bioprinting concept for the production of potentially biocompatible polymers with thiol-functionalized surfaces usable for subsequent functionalization. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/2041731417744485?download=true |
| ISSN | 20417314 |
| Volume Number | 8 |
| Journal | Journal of Tissue Engineering (TEJ) |
| e-ISSN | 20417314 |
| DOI | 10.1177/2041731417744485 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2017-12-21 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2017 |
| Subject Keyword | functional surface Bioprinting stereolithography thiol-ene photochemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biomaterials Biomedical Engineering |
