NDLI: Recellularization of decellularized heart valves: Progress toward the tissue-engineered heart valve

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Recellularization of decellularized heart valves: Progress toward the tissue-engineered heart valve

Content Provider	SAGE Publishing
Author	VeDepo, Mitchell C. Detamore, Michael S. Hopkins, Richard A. Converse, Gabriel L.
Copyright Year	2017
Abstract	The tissue-engineered heart valve portends a new era in the field of valve replacement. Decellularized heart valves are of great interest as a scaffold for the tissue-engineered heart valve due to their naturally bioactive composition, clinical relevance as a stand-alone implant, and partial recellularization in vivo. However, a significant challenge remains in realizing the tissue-engineered heart valve: assuring consistent recellularization of the entire valve leaflets by phenotypically appropriate cells. Many creative strategies have pursued complete biological valve recellularization; however, identifying the optimal recellularization method, including in situ or in vitro recellularization and chemical and/or mechanical conditioning, has proven difficult. Furthermore, while many studies have focused on individual parameters for increasing valve interstitial recellularization, a general understanding of the interacting dynamics is likely necessary to achieve success. Therefore, the purpose of this review is to explore and compare the various processing strategies used for the decellularization and subsequent recellularization of tissue-engineered heart valves.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/2041731417726327?download=true
ISSN	20417314
Volume Number	8
Journal	Journal of Tissue Engineering (TEJ)
e-ISSN	20417314
DOI	10.1177/2041731417726327
Language	English
Publisher	Sage Publications UK
Publisher Date	2017-08-25
Publisher Place	London
Access Restriction	Open
Rights Holder	© The Author(s) 2017
Subject Keyword	recellularization Tissue-engineered heart valve decellularization
Content Type	Text
Resource Type	Article
Subject	Medicine Biomaterials Biomedical Engineering

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