NDLI: Impact of mechanical stretch on the cell behaviors of bone and surrounding tissues

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Impact of mechanical stretch on the cell behaviors of bone and surrounding tissues

Content Provider	SAGE Publishing
Author	Yu, Hye-Sun Kim, Jung-Ju Kim, Hae-Won Lewis, Mark P. Wall, Ivan
Copyright Year	2016
Abstract	Mechanical loading is recognized to play an important role in regulating the behaviors of cells in bone and surrounding tissues in vivo. Many in vitro studies have been conducted to determine the effects of mechanical loading on individual cell types of the tissues. In this review, we focus specifically on the use of the Flexercell system as a tool for studying cellular responses to mechanical stretch. We assess the literature describing the impact of mechanical stretch on different cell types from bone, muscle, tendon, ligament, and cartilage, describing individual cell phenotype responses. In addition, we review evidence regarding the mechanotransduction pathways that are activated to potentiate these phenotype responses in different cell populations.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/2041731415618342?download=true
ISSN	20417314
Volume Number	7
Journal	Journal of Tissue Engineering (TEJ)
e-ISSN	20417314
DOI	10.1177/2041731415618342
Language	English
Publisher	Sage Publications UK
Publisher Date	2016-02-18
Publisher Place	London
Access Restriction	Open
Rights Holder	© The Author(s) 2016
Subject Keyword	bone cartilage tendon Flexercell ligament mechanical strain muscle
Content Type	Text
Resource Type	Article
Subject	Medicine Biomaterials Biomedical Engineering

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