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Diagnostic value of reflux episodes in gastroesophageal reflux-induced chronic cough: a novel predictive indicator
| Content Provider | SAGE Publishing |
|---|---|
| Author | Wang, Shengyuan Wen, Siwan Bai, Xiao Zhang, Mengru Zhu, Yiqing Wu, Mingyan Lu, Lihua Shi, Cuiqin Yu, Li Xu, Xianghuai |
| Copyright Year | 2022 |
| Abstract | Multichannel intraluminal impedance and pH-monitoring (MII-pH) is an essential testing modality for gastroesophageal reflux-induced chronic cough (GERC), while the existing diagnostic criteria still have some inherent defects. This study aimed to explore the diagnostic value of a direct and objective index, reflux episodes, and related parameters in MII-pH in different types of GERC.Methods:Patients with chronic cough suspected of gastroesophageal reflux disease who successfully received MII-pH were enrolled. The differences in MII-pH parameters were analyzed among patients with different etiologies and the predictive diagnostic value of reflux episodes and related parameters were analyzed in patients with GERC, acid GERC, and non-acid GERC, and compared with existing diagnostic criteria.Results:A total of 190 patients with suspected GERC who underwent MII-pH were enrolled; 131 of these patients were finally diagnosed with GERC. When the reflux episodes were used to diagnose GERC, the area under the curve (AUC) was 0.684; when the acid reflux episodes and the ratio of acid reflux episodes were used to diagnose acid GERC, the AUCs were 0.769 and 0.854; when the non-acid reflux episodes and the ratio of non-acid reflux episodes were used to diagnose non-acid GERC, the AUCs were 0.735 and 0.705, respectively. When the non-acid reflux episodes > 58 and the proportion of non-acid reflux episodes > 68.18% were used alone or in combination to diagnose non-acid GERC, their diagnostic value was significantly better than SAP or SI (all ps < 0.05).Conclusion:The number of reflux episodes has a good diagnostic value for GERC, especially in the diagnosis of non-acid GERC. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/20406223221117455?download=true |
| ISSN | 20406223 |
| Volume Number | 13 |
| Journal | Therapeutic Advances in Chronic Disease (TAJ) |
| e-ISSN | 20406231 |
| DOI | 10.1177/20406223221117455 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2022-08-17 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s), 2022 |
| Subject Keyword | gastroesophageal reflux cough multichannel intraluminal impedance-pH monitoring diagnosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
