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The Augmentation of a Collagen/Glycosaminoglycan Biphasic Osteochondral Scaffold with Platelet-Rich Plasma and Concentrated Bone Marrow Aspirate for Osteochondral Defect Repair in Sheep : A Pilot Study
| Content Provider | SAGE Publishing |
|---|---|
| Author | Getgood, Alan Henson, Frances Skelton, Carrie Herrera, Emilio Brooks, Roger Fortier, Lisa A. Rushton, Neil |
| Copyright Year | 2012 |
| Abstract | Objective:This study investigates the combination of platelet-rich plasma (PRP) or concentrated bone marrow aspirate (CBMA) with a biphasic collagen/glycosaminoglycan (GAG) osteochondral scaffold for the treatment of osteochondral defects in sheep.Design:Acute osteochondral defects were created in the medial femoral condyle (MFC) and the lateral trochlea sulcus (LTS) of 24 sheep (n = 6). Defects were left empty or filled with a 6 × 6-mm scaffold, either on its own or in combination with PRP or CBMA. Outcome measures at 6 months included mechanical testing, International Cartilage Repair Society (ICRS) repair score, modified O’Driscoll histology score, qualitative histology, and immunohistochemistry for type I, II, and VI collagen.Results:No differences in mechanical properties, ICRS repair score, or modified O’Driscoll score were detected between the 4 groups. However, qualitative assessments of the histological architecture, Safranin O content, and collagen immunohistochemistry indicated that in the PRP/scaffold groups, there was a more hyaline cartilage–like tissue repair. In addition, the addition of CBMA and PRP to the scaffold reduced cyst formation in the subchondral bone of healed lesions.Conclusion:There was more hyaline cartilage–like tissue formed in the PRP/scaffold group and less subchondral cystic lesion formation in the CBMA and PRP/scaffold groups, although there were no quantitative differences in the repair tissue formed. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1947603512444597?download=true |
| Starting Page | 351 |
| Ending Page | 363 |
| Page Count | 13 |
| ISSN | 19476035 |
| Issue Number | 4 |
| Volume Number | 3 |
| Journal | Cartilage (CAR) |
| e-ISSN | 19476043 |
| DOI | 10.1177/1947603512444597 |
| Language | English |
| Publisher | Sage Publications CA |
| Publisher Date | 2012-05-04 |
| Publisher Place | Los Angeles |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2012 |
| Subject Keyword | cartilage repair osteochondral scaffold platelet rich plasma |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Physical Therapy, Sports Therapy and Rehabilitation Biomedical Engineering |
