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Antitumor and Aedes aegypti Larvicidal Activities of Essential Oils From Piper klotzschianum, P. hispidum, and P. arboreum
| Content Provider | SAGE Publishing |
|---|---|
| Author | Lima, Rafaely N. Ribeiro, Adauto S. Gilvandete M.P. Santiago Cinara O. d´S. Costa Soares, Milena B. Bezerra, Daniel P. Shanmugam, Saravanan Lisiane dos S. Freitas Alves, Pericles B. |
| Copyright Year | 2019 |
| Abstract | The chemical constituents of essential oils extracted by hydrodistillation from Piper klotzschianum, P. hispidum, and P. arboreum, collected from the remaining Atlantic forest in Sergipe State, were characterized and submitted to cytotoxic and larvicidal activity assays. The major constituents identified (stems, fresh, and dried leaves) were (E)-caryophyllene (16.8%) and bicyclogermacrene (21.6%). Germacrene D (22.8%) was identified only in P. klotzschianum and P. hispidum. A high percentage of β-pinene (27.2%) and α-pinene (7.2%) were present in P. klotzschianum stems and δ-3-carene in the fresh and dried leaves of P. hispidum (17.4% and 19.1%, respectively). Piper klotzschianum showed the best cytotoxic activity, inhibiting human hepatocellular carcinoma (27.3 µg/mL), human promyelocytic leukemia (33.8 µg/mL), and murine melanoma (37.9 µg/mL) cell lines. Larvicidal activity was also tested and the essential oil from the dried leaves of P. klotzschianum was the most potent against Aedes aegypti larvae, with an LC50 value of 122.4 µg/mL. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1934578X19863932?download=true |
| ISSN | 1934578X |
| Issue Number | 7 |
| Volume Number | 14 |
| Journal | Natural Product Communications (NPX) |
| e-ISSN | 15559475 |
| DOI | 10.1177/1934578X19863932 |
| Language | English |
| Publisher | Sage Publications CA |
| Publisher Date | 2019-07-17 |
| Publisher Place | Los Angeles |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2019 |
| Subject Keyword | Piper Aedes aegypti essential oil cytotoxicity larvicidal |
| Content Type | Text |
| Resource Type | Article |
| Subject | Plant Science Drug Discovery Pharmacology Complementary and Alternative Medicine |
