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Baicalin Administered Orally After Ischemia/Reperfusion Alleviated Brain Injury in Mice by Inhibiting Inflammation and Edema
| Content Provider | SAGE Publishing |
|---|---|
| Author | Lee, Byoungho Lim, Chiyeon Lim, Sehyun Cho, Suin |
| Copyright Year | 2019 |
| Abstract | Baicalin is a natural product isolated from Scutellaria genus and has been reported to have many different pharmacological activities, which include anti-viral, anti-inflammatory, and anti-allergic effects. We investigated the effects of baicalin administered after I/R-induced brain injury in a mouse model. I/R-induced brain injury was induced by MCAO for 2 h. Baicalin was orally administered to mice once daily for 2 consecutive days after 2 h of reperfusion. Single daily oral administrations of baicalin at 10, 30, or 100 mg/kg/day for 2 consecutively days after I/R significantly reduced infarct volumes, edema indices, and water contents in mouse brains, serum levels of AQP-4. IL-1β, TNF-α, and ROS, and lipid peroxidation levels in brain ipsilateral hemispheres were suppressed by baicalin. This result is believed to be due to the anti-inflammatory effect of baicalin and its downregulation of AQP-4 protein expression in affected brain tissues after I/R-induced brain injury in mice. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1934578X19843032?download=true |
| ISSN | 1934578X |
| Issue Number | 5 |
| Volume Number | 14 |
| Journal | Natural Product Communications (NPX) |
| e-ISSN | 15559475 |
| DOI | 10.1177/1934578X19843032 |
| Language | English |
| Publisher | Sage Publications CA |
| Publisher Date | 2019-05-21 |
| Publisher Place | Los Angeles |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2019 |
| Subject Keyword | aquaporin-4 baicalin ischemia/reperfusion injury inflammation brain edema |
| Content Type | Text |
| Resource Type | Article |
| Subject | Plant Science Drug Discovery Pharmacology Complementary and Alternative Medicine |
