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Next-generation androgen receptor inhibitors in non-metastatic castration-resistant prostate cancer
| Content Provider | SAGE Publishing |
|---|---|
| Author | Lavaud, Pernelle Dumont, Clément Thibault, Constance Albiges, Laurence Baciarello, Giulia Colomba, Emeline Flippot, Ronan Fuerea, Alina Loriot, Yohann Fizazi, Karim |
| Copyright Year | 2020 |
| Abstract | Until recently, continuing androgen deprivation therapy (ADT) and closely monitoring patients until evolution towards metastatic castration-resistant prostate cancer (CRPC) were recommended in men with non-metastatic CRPC (nmCRPC). Because delaying the development of metastases and symptoms in these patients is a major issue, several trials have investigated next-generation androgen receptor (AR) axis inhibitors such as apalutamide, darolutamide, and enzalutamide in this setting. This review summarizes the recent advances in the management of nmCRPC, highlighting the favourable impact of next-generation AR inhibitors on metastases-free survival, overall survival and other clinically meaningful endpoints. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1758835920978134?download=true |
| ISSN | 17588359 |
| Volume Number | 12 |
| Journal | Therapeutic Advances in Medical Oncology (TAM) |
| e-ISSN | 17588359 |
| DOI | 10.1177/1758835920978134 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2020-12-23 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s), 2020 |
| Subject Keyword | non-metastatic setting castration resistance prostate cancer next generation androgen receptor inhibitors darolutamide enzalutamide apalutamide |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
