NDLI: PARP inhibitor combinations in prostate cancer

Content Provider	SAGE Publishing
Author	Pezaro, Carmel
Copyright Year	2020
Abstract	Polyadenosine-diphosphate-ribose polymerase (PARP) inhibitors cause deoxyribonucleic acid (DNA) damage that can be lethal to cells with deficient repair mechanisms. A number of PARP inhibitors are being tested as treatments for men with prostate cancer, both as monotherapies and in combinations that are based on purported synergies in treatment effect. While the initial single-agent development focused on men with identified deficiencies in DNA-repair pathways, broader patient populations are being considered for combination approaches. This review summarizes the current clinical development of PARP inhibitors and explores the rationale for novel combination strategies.
Related Links	https://journals.sagepub.com/doi/pdf/10.1177/1758835919897537?download=true
ISSN	17588359
Volume Number	12
Journal	Therapeutic Advances in Medical Oncology (TAM)
e-ISSN	17588359
DOI	10.1177/1758835919897537
Language	English
Publisher	Sage Publications UK
Publisher Date	2020-03-18
Publisher Place	London
Access Restriction	Open
Rights Holder	© The Author(s), 2020
Subject Keyword	DNA-damage repair PARP combinations synthetic lethality PARP inhibitor prostate cancer
Content Type	Text
Resource Type	Article
Subject	Oncology

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PARP inhibitor combinations in prostate cancer