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Association between circulating tumor cells and peripheral blood monocytes in metastatic breast cancer
| Content Provider | SAGE Publishing |
|---|---|
| Author | Giorgi, Ugo De Mego, Michal Scarpi, Emanuela Giordano, Antonio Giuliano, Mario Valero, Vicente Alvarez, Ricardo H. Ueno, Naoto T. Cristofanilli, Massimo Reuben, James M. |
| Copyright Year | 2019 |
| Abstract | We retrospectively evaluated the correlation between a baseline measurement of circulating tumor cells (CTCs) and inflammation-based scores in patients with metastatic breast cancer (MBC).Methods:The optimal value of inflammation-based scores as the neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), monocyte–lymphocyte ratio (MLR) and systemic immune-inflammation index (SII) to predict survival was determined and compared with CTC <5 or ⩾5 per 7.5 ml of blood.Results:In the overall population of 516 women with MBC, CTCs correlated with peripheral blood monocytes (p = 0.008) and neutrophils (p = 0.038). In triple-negative tumors, CTCs correlated with monocyte count (p = 0.009); in HER2+ tumors, CTCs correlated with neutrophil count (p = 0.009), with a trend versus monocyte count (p = 0.061), whereas no correlation was found in HER2– estrogen receptor-positive (ER+) tumors. In multivariate analysis only monocytes were associated with ⩾5 CTCs (OR = 2.72, 95% CI 1.09–6.80, p = 0.033). In multivariable analysis for predictors of overall survival, CTC (⩾5 versus <5), number of metastatic sites (>1 versus 1), tumor subtypes (triple-negative versus HER2– ER+ tumors) and MLR only remained significant.Conclusions:CTC and MLR are predictors of overall survival in MBC. CTC correlates with monocytes, in particular in triple-negative tumors. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1758835919866065?download=true |
| ISSN | 17588359 |
| Volume Number | 11 |
| Journal | Therapeutic Advances in Medical Oncology (TAM) |
| e-ISSN | 17588359 |
| DOI | 10.1177/1758835919866065 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2019-08-14 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s), 2019 |
| Subject Keyword | breast cancer inflammation CTC circulating tumor cells monocytes prognosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
