Loading...
Please wait, while we are loading the content...
Similar Documents
The role of MRI/TRUS fusion biopsy in the diagnosis of clinically significant prostate cancer
| Content Provider | SAGE Publishing |
|---|---|
| Author | Benelli, Andrea Vaccaro, Chiara Guzzo, Sonia Nedbal, Carlotta Varca, Virginia Gregori, Andrea |
| Copyright Year | 2020 |
| Abstract | The aim of this work is to evaluate the detection rate of magnetic resonance imaging/transrectal ultrasound (MRI/TRUS) fusion-guided biopsy for clinically significant prostate cancers (Cs PCas), with particular interest in biopsy-naive patients and patients in active surveillance. MRI-targeted biopsy improves cancer detection rate (DR) in patients with prior negative biopsies; the current literature focuses on biopsy naive patients. We also evaluated the pathologic concordance between biopsies and surgical specimens.Methods:MRI/TRUS fusion-guided biopsies were performed between February 2016 and February 2019. Patients with previous negative biopsies, biopsy-naive or in active surveillance (AS) were included. Cs PCas were defined through Epstein’s criteria.Results:A total of 416 men were enrolled. The overall DRs and Cs PCa DRs were 49% and 34.3%, respectively. Cs PCas were 17.2%, 44.9% and 73.4%, respectively for PI-RADS 3, 4 or 5. Among biopsy-naive patients, 34.8% were found to have a Cs PCa, while a 43.6% tumour upgrading was achieved in men with a low risk of PCa. In patients who underwent radical prostatectomy (RP), the concordance between biopsy Gleason score (GS) (bGS) and pathological GS (pGS) was 90.8%.Conclusion:Our study highlights the role of MRI/TRUS fusion prostate biopsy in the detection of PCa in patients with previous negative biopsies focusing on Cs PCa diagnosis. The MRI/TRUS fusion biopsy is also emerging as a diagnostic tool in biopsy-naïve patients and deserves a fundamental role in AS protocols. A greater concordance between bGS and pGS can be achieved with targeted biopsies. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1756287220916613?download=true |
| ISSN | 17562872 |
| Volume Number | 12 |
| Journal | Therapeutic Advances in Urology (TAU) |
| e-ISSN | 17562880 |
| DOI | 10.1177/1756287220916613 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2020-05-18 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s), 2020 |
| Subject Keyword | PIRADS multiparametric MRI fusion biopsy prostate cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Urology |
