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Drug-induced liver injury: a comprehensive review
| Content Provider | SAGE Publishing |
|---|---|
| Author | Hosack, Tom Damry, Djamil Biswas, Sujata |
| Copyright Year | 2023 |
| Abstract | Drug-induced liver injury (DILI) remains a challenge in clinical practice and is still a diagnosis of exclusion. Although it has a low incidence amongst the general population, DILI accounts for most cases of acute liver failure with a fatality rate of up to 50%. While multiple mechanisms of DILI have been postulated, there is no clear causal relationship between drugs, risk factors and mechanisms of DILI. Current best practice relies on a combination of high clinical suspicion, thorough clinical history of risk factors and timeline, and extensive hepatological investigations as supported by the international Roussel Uclaf Causality Assessment Method criteria, the latter considered a key diagnostic algorithm for DILI. This review focuses on DILI classification, risk factors, clinical evaluation, future biomarkers and management, with the aim of facilitating physicians to correctly identify DILI early in presentation. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/17562848231163410?download=true |
| ISSN | 17562848 |
| Volume Number | 16 |
| Journal | Therapeutic Advances in Gastroenterology (TAG) |
| e-ISSN | 17562848 |
| DOI | 10.1177/17562848231163410 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2023-03-21 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s), 2023 |
| Subject Keyword | acute liver failure DILI RUCAM acute liver injury acute hepatitis drug-induced liver injury |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology |
