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Propensity score matching analysis for adverse events of EUS-guided biliary drainage in advanced elderly patients (PEACE study)
| Content Provider | SAGE Publishing |
|---|---|
| Author | Ogura, Takeshi Ishiwatari, Hirotoshi Fujimori, Nao Iwasaki, Eisuke Ishikawa, Kazuma Satoh, Tatsunori Kaneko, Junichi Sato, Junya Oono, Takamasa Matsumoto, Kazuhide Fukuhara, Seiichiro Kayashima, Atsuto Hakoda, Akitoshi Higuchi, Kazuhide |
| Copyright Year | 2022 |
| Abstract | Several studies have suggested that elderly patients, as well as younger patients, can be safely treated using endoscopic retrograde cholangiopancreatography (ERCP). However, endoscopic ultrasound-guided biliary drainage (EUS-BD) has not been clinically evaluated for very elderly patients. The present multicenter, retrospective study aimed to determine the safety of EUS-BD for advanced elderly patients.Method:Patients who underwent EUS-BD during this period were retrospectively enrolled, and they were divided into two groups based on age: group A (age < 75 years) and group B (age ⩾ 75). In this study, capnographic monitoring was used only for elderly patients (age ⩾ 75 years).Results:A total of 271 patients who underwent EUS-BD were enrolled in this study (group A = 177, group B = 94). The types of adverse events that were associated with EUS-BD was observed in 38 patients, and they did not differ significantly between two groups (p = 0.855). This result was confirmed after propensity score matching (p = 0.510). Adverse events were associated with sedation after propensity score matching; hypoxemia (p = 0.012) and severe hypoxemia (p = 0.003) were significantly higher in group A compared with group B. According to logistic regression analysis, monitoring (non-capnography) was also only risk factor (odds ratio: 0.317, 95% confidence interval: 0.143–0.705; p = 0.005) for sedation-related adverse events.Conclusion:In conclusion, EUS-BD could be safety performed in advanced elderly patients, the same as in younger patients. Also, capnographic monitoring might be helpful in case of sedation by a gastroenterologist in a non-intubated patient. Further prospective, randomized studies are needed to confirm these conclusions. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/17562848221092612?download=true |
| ISSN | 17562848 |
| Volume Number | 15 |
| Journal | Therapeutic Advances in Gastroenterology (TAG) |
| e-ISSN | 17562848 |
| DOI | 10.1177/17562848221092612 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2022-05-17 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s), 2022 |
| Subject Keyword | elderly adverse event EUS EUS-guided biliary drainage sedation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology |
