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Faecal biomarkers for screening small bowel inflammation in patients with Crohn’s disease: a prospective study
| Content Provider | SAGE Publishing |
|---|---|
| Author | Shimoyama, Takahiro Yamamoto, Takayuki Umegae, Satoru Matsumoto, Koichi |
| Copyright Year | 2017 |
| Abstract | The value of faecal biomarkers for screening small bowel inflammation in patients with Crohn’s disease (CD) remains to be elucidated. This prospective study was to evaluate the utility of faecal biomarkers for detecting small intestinal inflammation.Methods:A total of 122 consecutive patients with a diagnosis of CD in the small intestine were screened for eligibility. Computed tomography enterography (CTE) was undertaken to evaluate small bowel inflammation followed by colonoscopy to confirm no large bowel involvement. Seventy eligible patients with inflammation confined to the small intestine were included. Faecal samples were collected for assaying calprotectin, lactoferrin and haemoglobin. For assessing the degree of small bowel inflammation, a semi-quantitative scoring system (CTE0, normal; CTE1, mild; CTE2, moderate; CTE3, severe) was applied.Results:The median calprotectin, lactoferrin and haemoglobin levels were significantly higher in patients with small bowel inflammation, CTE scores 1–3 (n = 42) versus 0 (n = 28): calprotectin, 330 versus 40 ng/ml, p < 0.0001; lactoferrin, 14 versus 3 ng/ml, p < 0.0001; haemoglobin, 29.5 versus 6.5 ng/ml, p = 0.005. There was a strong positive relationship between the faecal biomarkers and CTE score: calprotectin, p < 0.0001; lactoferrin, p < 0.0001; haemoglobin, p = 0.0004. A cutoff value of 140 ng/ml for calprotectin had a sensitivity of 69% and a specificity of 82% with an area under the receiver operating characteristic curve (AUC) of 0.82 to detect small bowel inflammation (CTE scores 1–3), while lactoferrin 6 ng/ml had a sensitivity of 69% and a specificity of 79% with an AUC of 0.83, and haemoglobin 9 ng/ml showed a sensitivity of 71% and a specificity of 39% with an AUC of 0.70.Conclusions:Faecal calprotectin, lactoferrin, and to a lesser degree haemoglobin are relevant biomarkers for screening small bowel inflammation in CD patients without large bowel involvement. Further well-designed large-scale studies in this clinical setting should strengthen our findings. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/1756283X17717683?download=true |
| Starting Page | 577 |
| Ending Page | 587 |
| Page Count | 11 |
| ISSN | 17562848 |
| Issue Number | 8 |
| Volume Number | 10 |
| Journal | Therapeutic Advances in Gastroenterology (TAG) |
| e-ISSN | 17562848 |
| DOI | 10.1177/1756283X17717683 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2017-07-04 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s), 2017 |
| Subject Keyword | Crohn’s disease calprotectin haemoglobin faecal biomarkers lactoferrin small bowel inflammation computed tomography enterography |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology |
