Loading...
Please wait, while we are loading the content...
Similar Documents
Synthesis of pyrophosphate analogues and their cytotoxic activities
| Content Provider | SAGE Publishing |
|---|---|
| Author | Nguyen, Van-Tai Pham, Minh-Quan Vu, Thi-Ha Tran, Thi-Hong-Ha Doan, Duy-Tien Nguyen, Dinh-Luyen Le, Phong Luu, Van-Chinh |
| Copyright Year | 2021 |
| Abstract | Six pyrophosphate analogues are prepared from zerumbone, murrayafoline A, acridone, and 4-hydroxycoumarin via 1,3-dipolar cycloaddition reactions. Their in vitro cytotoxic activity is evaluated against HepG2, LU-1, and HeLa cancer cell lines. Among them, diisopropyl ((ethoxy((4-((1-methoxy-3-methyl-9H-carbazol-9-yl)methyl)-1H-1,2,3-triazol-1-yl)methyl)phosphoryl)methyl)phosphonate (6a) and diisopropyl ((ethoxy((4-(((3-methyl-9H-carbazol-1-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)methyl)phosphoryl)methyl)phosphonate (6b) are found to show activity against HepG2, LU-1, and HeLa cancer cell lines, with IC50 values ranging from 7.31 to 17.88 μM. |
| Related Links | https://journals.sagepub.com/doi/pdf/10.1177/17475198211043439?download=true |
| Starting Page | 992 |
| Ending Page | 997 |
| Page Count | 6 |
| ISSN | 17475198 |
| Issue Number | 11-12 |
| Volume Number | 45 |
| Journal | Journal of Chemical Research (CHL) |
| e-ISSN | 20476507 |
| DOI | 10.1177/17475198211043439 |
| Language | English |
| Publisher | Sage Publications UK |
| Publisher Date | 2021-09-15 |
| Publisher Place | London |
| Access Restriction | Open |
| Rights Holder | © The Author(s) 2021 |
| Subject Keyword | pyrophosphate analogues triazole cytotoxic zerumbone murrayafoline A |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry |
